D-dimer Prognostic Marker of Cerebral Infarction After Revascularization Procedure

Recruiting

• Conditions: Cerebral Infarction; Cerebral Infarction Recovery

• Registration Number: NCT04938479
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Cerebral infarction is the leading cause of acquired disability in adults. Absence of biological marker used in current practice and identified as a prognostic factor for recovery. D-dimers are degradation products of stabilized fibrin translating an activation of coagulation whatever the cause. Studies have shown that increased D-dimer levels in patients with MI is associated with a higher mortality rate, the link with post-intervention non-revascularization has been demonstrate.

The purpose of this project is to search for a correlation between the level of D-dimer and the degree of recovery evaluated by the NIHSS score

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-15
• Study First Submitted: 2021-06-17
• Study First Submitted QC: 2021-06-17
• Study First Posted: 2021-06-24
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-09
• Last Update Posted: 2023-05-10
• Primary Completion: 2023-09
• Study Completion: 2023-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients aged 18 to 65
• Cerebral infarctions undergoing a revascularization procedure by thrombolysis and / or thrombectomy, at the Amiens University Hospital between January 2015 and December 2020.
• Patients having benefited from a D-dimer assay (during their stay)

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between D-dimer concentration and NIHSS score	6 months	NIHSS score is based on the clinical neurological examination of the patient. Validated by the scientific community of vascular neurology, among other things in projective clinical research. This score has high inter-observer reproducibility Expressed quantitatively on a scale of 0 to 42 for the NIHSS score A high value of the NIHSS score indicates poor recovery.
Correlation between D-dimer concentration and the Rankin score	6 months	Rankin Scale collected by the neurologist in consultation 3-6 months post stroke.; Expressed quantitatively on a scale of 0 to 6 for the Rankin scale. A high value of the Rankin scale indicates poor recovery.

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France