ACTRN12623000116628招募中2 期
The Acute Effects of Translingual Glyceryl Trinitrate (GTN) on Exercise Parameters in Patients with Left Ventricular Assist Devices
St Vincent's Hospital Sydney0 个研究点目标入组 20 人开始时间: 2023年2月3日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Willingness to give written informed consent and willingness to participate to and comply with the study.
- •Age greater or equal to 18
- •Clinically stable: no new additional disease-modifying drug (angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, sacubitril, beta-blocker), no change in disease-modifying drug dosage more than 50% (excluded: diuretics), no recent (previous 3 months) admission to the hospital with decompensated heart failure.
- •Ambulatory.
- •>8 weeks after pump insertion.
排除标准
- •Active, uncontrolled infection.
- •Exercise induced myocardial ischaemia or significant arrhythmias.
- •Recent acute coronary syndrome (<6 weeks).
- •Limiting musculoskeletal disorder.
- •Poor exercise capacity on 6MWT
- •Significant lung disease that is likely to limit exercise capacity
- •Exercise induced asthma
- •Regular sildenafil use.
- •Hypotension (mean arterial pressure <65mmHg)
研究者
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