A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary Hyperparathyroidism
- Conditions
- Primary HyperparathyroidismPrimary Hyperparathyroidism Due to Adenoma
- Interventions
- Diagnostic Test: 11C-choline PET/CT
- Registration Number
- NCT04608253
- Lead Sponsor
- University Medical Center Groningen
- Brief Summary
The leading cause of primary hyperparathyroidism (pHPT) is a solitary adenoma (89%). The treatment of pHPT is generally surgical removal of the overactive parathyroid gland(s). Since a solitary adenoma is the predominant cause, parathyroid surgery is preferably performed through a minimally invasive parathyroidectomy (MIP) in which only the suspected adenoma causing the pHPT is resected in a focused manner. To facilitate the performance of a MIP, accurate preoperative imaging is pivotal. This study aimed to analyze the diagnostic performance of 11C-choline PET/CT after prior negative or discordant first-line imaging in patients with pHPT undergoing parathyroid surgery with an optimized imaging protocol.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
Patients eligible for inclusion were ≥18 years old, diagnosed with biochemically confirmed pHPT, underwent a MIBI-SPECT/CT and/or cUS with negative or discordant results, and underwent a 11C-choline PET/CT followed by parathyroidectomy.
Patients were excluded if they were known to have a germline mutation predisposing for familial hypocalciuric hypercalcemia (FHH).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description All enrolled subjects received an 11C-choline PET/CT prior to enrollment. 11C-choline PET/CT Patients with biochemically proven primary hyperparathyroidism who underwent parathyroid surgery after localization by means of 11C-choline PET/CT and negative or discordant first-line imaging
- Primary Outcome Measures
Name Time Method Accuracy of 11C-choline PET/CT Until 6 months after parathyroid surgery Per-lesion accuracy of 11C-choline PET/CT for the detection of overactive parathyroid glands
Sensitivity of 11C-choline PET/CT Until 6 months after parathyroid surgery Per-lesion sensitivity of 11C-choline PET/CT for the detection of overactive parathyroid glands
Positive predictive value of 11C-choline PET/CT Until 6 months after parathyroid surgery Per-lesion positive predictive value of 11C-choline PET/CT for the detection of overactive parathyroid glands
- Secondary Outcome Measures
Name Time Method