Heart Revascularisation Trial - UK

Not Applicable

Completed

• Conditions: Topic: Cardiovascular; Subtopic: Cardiovascular (all Subtopics); Disease: Cardiovascular; Circulatory System; Stress-induced ischaemia

• Registration Number: ISRCTN66339600
• Lead Sponsor: Hull and East Yorkshire Hospitals NHS Trust (UK)

Brief Summary

2011 results in: https://www.ncbi.nlm.nih.gov/pubmed/21156659 (added 13/06/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2006-11-20
• Study Start: 2010-07-30
• Last Update Posted: 1 July 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 138

Inclusion Criteria

1. Heart failure (in the investigators opinion) requiring chronic diuretic therapy
2. Coronary disease as the cause of heart failure as evidenced by a history of previous myocardial infarction, previous revascularisation or previous angiography
3. Left ventricular systolic dysfunction (ejection fraction less than 35%)
4. Stress-induced myocardial ischaemia or evidence of myocardial hibernation/stunning affecting five or more left ventricular segments in a 16-segment model
5. Male and female, lower age limit of 18 years

Exclusion Criteria

1. Inability to give written informed consent. No age limits are stipulated but patients will have to be over 18 years to give consent and some patients may be considered too frail to survive surgery and would be excluded.
2. Patients who are not candidates for coronary artery bypass graft (CABG) surgery because of frailty or serious co-morbidity, e.g., severe lung disease, metastatic carcinoma. N.B. Some patients will be candidates for percutaneous transluminal coronary angioplasty (PTCA) but prior to randomisation (i.e. prior to doing an angiogram for study purposes) the investigator should be willing to send the patient to CABG surgery in case that is the preferred mode of revascularisation.
3. Unstable angina, myocardial infarction or stroke within the preceding 2 months
4. Patients being considered for revascularisation for the relief of chest pain (angina) or for valve surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified