NCT00473915已完成4 期
Intranasal Steroids Prevent Antigen-Induced Hyperresponsiveness of the Nasal Ocular Response
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in ocular symptoms
研究概览
简要总结
Eye symptoms of tearing, redness and itch frequently occur in patients with allergic rhinitis or hayfever. The purpose of this study is to learn whether placing allergen (the substance that causes allergies) in the nose several days in a row will cause an increase in eye symptoms and whether receiving a nasal steroid spray will prevent these eye symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females between 18 and 45 years of age.
- •History of grass and/or ragweed allergic rhinitis.
- •Positive skin test to grass and/or ragweed antigen.
- •Positive response to screening nasal challenge.
排除标准
- •Physical signs or symptoms suggestive of renal, hepatic or cardiovascular disease.
- •Pregnant or lactating women.
- •Upper respiratory infection within 14 days of study start.
结局指标
主要结局
Change in ocular symptoms
时间窗: between days 1 and 3
次要结局
- number of eosinophils(between days 1 and 3)
研究者
Robert Naclerio
Professor
University of Chicago
研究点 (2)
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