NCT02917486CompletedNot Applicable
EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION
Rennes University Hospital2 sites in 1 country44 target enrollmentStarted: January 1, 2016Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 44
- Locations
- 2
- Primary Endpoint
- Measure exposure to piperacillin
Study Overview
Brief Summary
The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation.
The exhibition is evaluated by population pharmacokinetic modeling.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age over 18 years
- •Hospitalisation in intensive care
- •Treatment with ECMO or without ECMO
- •Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours
- •With an arterial catheter
- •Patient Information or their next of kin according to the patients status.
Exclusion Criteria
- •Pregnancy
- •Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty
Outcomes
Primary Outcomes
Measure exposure to piperacillin
Time Frame: Day 1
evaluated by population pharmacokinetic modeling and is defined by the time during which the antibiotic concentration is greater than 4 times the critical concentration of the germ to treat
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (2)
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