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Clinical Trials/NCT02917486
NCT02917486CompletedNot Applicable

EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

Rennes University Hospital2 sites in 1 country44 target enrollmentStarted: January 1, 2016Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
44
Locations
2
Primary Endpoint
Measure exposure to piperacillin
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation.

The exhibition is evaluated by population pharmacokinetic modeling.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Age over 18 years
  • •Hospitalisation in intensive care
  • •Treatment with ECMO or without ECMO
  • •Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours
  • •With an arterial catheter
  • •Patient Information or their next of kin according to the patients status.

Exclusion Criteria

  • •Pregnancy
  • •Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty

Outcomes

Primary Outcomes

Measure exposure to piperacillin

Time Frame: Day 1

evaluated by population pharmacokinetic modeling and is defined by the time during which the antibiotic concentration is greater than 4 times the critical concentration of the germ to treat

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Rennes University Hospital
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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