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Clinical Trials/ISRCTN49693355
ISRCTN49693355
Completed
未知

A randomised prospective double-blind, placebo controlled trial of prophylactic oral levofloxacin following chemotherapy for lymphoma and solid tumours

Cancer Research UK (CRUK) (UK)0 sites1,500 target enrollmentJuly 1, 2001
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ConditionsBreast, testis, lung (small cell), lymphoma (Hodgkins), lymphoma (non-Hodgkins)CancerComplications of procedures, not elsewhere classified

Overview

Phase
未知
Intervention
Not specified
Conditions
Breast, testis, lung (small cell), lymphoma (Hodgkins), lymphoma (non-Hodgkins)
Sponsor
Cancer Research UK (CRUK) (UK)
Enrollment
1500
Status
Completed
Last Updated
4 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

2005 Results article in http://www.ncbi.nlm.nih.gov/pubmed/16148284 results

Registry
who.int
Start Date
July 1, 2001
End Date
December 31, 2003
Last Updated
4 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
Cancer Research UK (CRUK) (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Adult who has given informed consent
  • •2\. Solid tumour or lymphoma
  • •3\. First cycle of anti\-neoplastic chemotherapy
  • •4\. Anticipated neutrophil nadir \<0\.5 x 10^9/l
  • •5\. Normal serum creatinine or creatinine clearance \>40 ml/min
  • •6\. Adequate contraceptive measures in place

Exclusion Criteria

  • •1\. Human Immunodeficiency Virus (HIV) positive
  • •2\. Pregnant or breast feeding
  • •3\. Epileptic
  • •4\. Planned granulocyte colony\-stimulating factor (GCSF) or stem cell support
  • •5\. Currently taking antibacterial therapy or prophylaxis
  • •6\. History of adverse effects caused by fluoroquinolone agent
  • •7\. Previous participation in the Significant trial

Outcomes

Primary Outcomes

Not specified

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