Efficacy of a Structured Exercise Prescription Program Over Anthropometric, Metabolic and Fitness Parameters in Obese Children and Adolescents Included in a Multicomponent Lifestyle Intervention Program. Randomized Clinical Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
- Enrollment
- 140
- Locations
- 1
- Primary Endpoint
- VO2 max
- Last Updated
- 7 years ago
Overview
Brief Summary
This controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity with a control group that will be enrolled in a multicomponent program without structured personalized exercise prescription. All children will be followed for a period of 6 months.
The parameters that will be evaluated between groups are physical fitness, anthropometry, metabolic (glucose oral tolerance curve, lipids, HOMA-IR, ISI-MATSUDA), early cardiovascular damage, inflammatory biomarkers, anxiety and depression scores, and allelic variants related to physical fitness.
Detailed Description
This controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity (study group) with a control group that will be enrolled in a multicomponent program without structured personalized exercise prescription. All children will be followed for a period of 6 months. The parameters that will be evaluated between groups are physical fitness (measured by VO2max, ECG at rest, biomechanics and dynamometry), anthropometric measurements (weight height, BMI, plicometry, bioimpedance, metabolic (glucose oral tolerance curve, lipids, HOMA-IR, ISI-MATSUDA), early cardiovascular damage (carotid intima-media thickness, atherogenic dyslipidemia), inflammatory biomarkers (leptin, adiponectin, IL-17, IL-10, INF-gamma, IL-6, IL-12, y TNF-alpha), anxiety and depression scores evaluated with Child Depression Inventory (CID) and -Trait Anxiety Inventory for Children (STAI-CH), and allelic variants related to physical fitness (ACTN, TRH2 y FTO).
Investigators
Nayely Garibay Nieto
Head of the Child and Adolescent Obesity Clinic
Hospital General de México Dr. Eduardo Liceaga
Eligibility Criteria
Inclusion Criteria
- •Patients with BMI ≥ Pc 95 and \< 35kg/m2 Both sexes Accepts to participate and signs informed consent
Exclusion Criteria
- •Presence of endocrine disease including type I and II diabetes mellitus Presence of arterial hypertension Presence of primary dyslipidemia Presence of infections at moment of enrollment Presence of systemic disease Presence of genetic disorder Medical treatment that may interfere with lipid or glucose metabolism Prolonged or acute immobilization Participated in a previous similar intervention
Outcomes
Primary Outcomes
VO2 max
Time Frame: 6 months
Changes in VO2 max as fitness indicator
OGTT
Time Frame: 6 months
Oral glucose tolerance test
Secondary Outcomes
- BMI(6 months)
- AST(6 months)
- ALT(6 months)
- GGT(6 months)
- Leptin(6 months)
- Adiponectin(6 months)
- Lean body mass(6 months)