NCT06475287尚未招募2 期
The Efficacy and Safety of HAIC Combined With TQB2450 and Anlotinib in Second-line Treatment of Advanced Hepatocellular Carcinoma: an Open, Single Arm Exploratory Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Objective response rate
研究概览
简要总结
Overall, although there are many options for second-line treatment of liver cancer, the ORR is mostly limited to within 20-30%, with a median PFS of 3-5 months and a median OS of 10-20 months. The overall situation is still unsatisfactory, with low objective tumor response rates and targeted immune resistance being the main reasons affecting treatment efficacy. Increasing local treatment or overcoming resistance is currently a hot research topic. The aim of this study is to explore the effectiveness and safety of HAIC combined with TQB2450 and anlotinib for second-line treatment of advanced HCC patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or non-pregnant female aged 18-80 years or older;
- •Diagnosed as advanced hepatocellular carcinoma (HCC) by histology, cytology, or clinical examination;
- •Signed informed consent form
- •The patient has received first-line treatment for hepatocellular carcinoma and the treatment has failed or is intolerable;
- •Previously received HAIC treatment containing platinum;
- •Early treatment allows for receiving tyrosine kinase inhibitor (TKI) treatment or bevacizumab treatment;
- •Allow to receive immunotherapy in the early stage;
- •At least one measurable lesion (according to RECIST 1.1 standard);
- •Tumor tissue samples before treatment (if available)；
- •Child Pugh A grade or ≤ 7 B grade within 14 days prior to enrollment;
- •HIV antibody test result was negative during screening
- •HIV antibody test result was negative during screening
- •Any acute, clinically significant treatment-related toxicity (caused by previous treatment) must have been alleviated to ≤ 1 level before enrollment in the study, except for hair loss
- •Patients with active hepatitis B virus (HBV) infection: HBV DNA<2000IU/mL obtained within 28 days before starting the study treatment, and received at least 7 days of anti HBV treatment (according to local standard treatment, such as entecavir) before joining the study, and were willing to continue to receive treatment during the study period; Patients with active hepatitis C virus (HCV) infection: HCVRNA<2000IU/mL obtained within 28 days prior to the start of study treatment, and who have received at least 7 days of anti HCV treatment before enrollment in the study and are willing to continue treatment during the study period
排除标准
- •Previously received treatment with mitoxantrone;
- •History of soft meningitis;
- •Current or past autoimmune diseases or immunodeficiencies;
- •Idiopathic pulmonary fibrosis, organizing pneumonia (such as bronchiolitis obliterans), drug-induced pneumonia or idiopathic pneumonia, or evidence of active pneumonia can be seen on screening chest computed tomography (CT) images. Allow radiation zone (fibrosis) to have radiation induced pneumonia;
- •Known active tuberculosis;
- •Within 3 months prior to the start of the study treatment, there was a significant cardiovascular disease, unstable arrhythmia, or unstable angina;
- •History of congenital long QT syndrome or corrected QT interval during screening>500ms ;
- •History of electrolyte disorders such as uncorrectable serum potassium, calcium, or magnesium;
- •Received major surgical treatment within 4 weeks prior to the start of the study (excluding diagnosis) or expected to undergo major surgical treatment during the study period;
- •Previously diagnosed with malignant tumors other than HCC within the 5 years prior to screening, excluding those with negligible risk of metastasis or death (e.g. 5-year OS rate>90%), such as fully treated in situ cervical cancer, non melanoma skin cancer, localized prostate cancer, in situ or stage I uterine cancer;
- •Within 4 weeks prior to the start of the study treatment, there was a severe infection, including but not limited to hospitalization due to complications such as infection, bacteremia, or severe pneumonia;
- •Administer therapeutic antibiotics orally or intravenously within 2 weeks prior to starting the study treatment. Patients who receive prophylactic antibiotics (such as preventing urinary tract infections or exacerbation of chronic obstructive pulmonary disease) are eligible to participate in the study;
- •Previous allogeneic stem cell or solid organ transplantation;
- •Received attenuated live vaccine treatment within 4 weeks prior to the start of the study, or expected to receive such vaccine during PD-1 monoclonal antibody treatment or within 5 months after the last dose of PD-1 monoclonal antibody;
- •Untreated or incompletely treated esophageal and/or gastric varicose patients with accompanying bleeding or high risk of bleeding;
- •Simultaneously infected with HBV and HCV;
- •Symptomatic, untreated, or gradually progressing central nervous system (CNS) metastases.
研究组 & 干预措施
HAIC combined with TQB2450 and Anlotinib
Experimental
干预措施: HAIC（Mitoxantrone+Raltitrexed）、anlotinib、TQB2450 (Drug)
结局指标
主要结局
Objective response rate
时间窗: 24 months
The proportion of patients whose tumors have shrunk to a certain amount and maintained for a certain period of time, including complete response and partial response
次要结局
未报告次要终点
研究者
Lu Wang, MD, PhD
Chief physician
Fudan University
研究点 (1)
Loading locations...
相似试验
招募中
2 期
Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning ModelHCCNCT06420440Chen Xiaoping160
尚未招募
4 期
Efficacy and Safety of Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model.HCCNCT06311916Chen Xiaoping312
尚未招募
2 期
Efficacy and Safety of HAIC in Combination With TQB2868 and Ramucirumab for Second-line Treatment of Advanced Hepatocellular CarcinomaHepatocellular Carcinoma，Bispecific Antibodies, HAIC, RamucirumabNCT06441019Fudan University42
Unknown
2 期
TACE Combinated With Sorafenib in Treating Patients With Unresectable Hepatocellular CarcinomaPHENYTOIN/SORAFENIB [VA Drug Interaction]Carcinoma, HepatocellularNCT01605734Shandong Cancer Hospital and Institute120
招募中
2 期
HAIC Combined With Camrelizumab and TKI for Unresectable Hepatocellular Carcinoma After TACE FailureUnresectable Hepatocellular CarcinomaNCT05135364Yue Han48