A Study Of Oral CP-690,550 As A Maintenance Therapy For Ulcerative Colitis

Phase 3

Completed

Conditions: Ulcerative Colitis

Interventions: Drug: Placebo
Drug: CP690,550
Drug: CP-690,550

Registration Number: NCT01458574

Lead Sponsor: Pfizer

Brief Summary: The study proposes to assess whether compared to placebo, CP-690,550 is effective, safe, and tolerable maintenance therapy in subjects with Ulcerative Colitis (UC). The study proposes to assess whether compared to placebo, CP-690,550 maintenance therapy more effectively achieves mucosal healing and improves quality of life in subjects with UC.The study proposes to assess CP-690,550 pharmacokinetic exposure during maintenance therapy in subjects over the age of 18 years with UC.

Detailed Description: Not available

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 593

Inclusion Criteria

Subjects who met study entry criteria and completed 8-week induction treatment from Study A3921094 or A3921095
Subjects who achieved clinical response in Study A3921094 or A3921095
Women of childbearing potential must test negative for pregnancy prior to study enrollment
Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures
Evidence of a personally signed and dated informed consent document(s) indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study.

Exclusion Criteria

Subjects who had major protocol violation (as determined by the Sponsor) in Study A3921094 or A3921095
Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, or clinical findings suggestive of Crohn's disease
Subjects who have had surgery for UC or in the opinion of the investigator, are likely to require surgery for UC during the study period.

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo Comparator	Placebo	-
CP-690,550 5 mg Arm	CP690,550	-
CP-690,550 10 mg Arm	CP-690,550	-

Primary Outcome Measures

Name	Time	Method
Percentage of Participants In Remission at Week 52	Week 52	Remission in participants was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of ulcerative colitis (UC). It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and physician global assessment (PGA), each subscore graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12 where higher score indicating higher disease severity.

Secondary Outcome Measures

Name	Time	Method
Percentage of Participants With Mucosal Healing at Week 24	Week 24	Mucosal healing in participants was defined by a mayo endoscopic subscore of 0 or 1. The mayo endoscopic subscore consisted of the findings of centrally read flexible sigmoidoscopy, graded from 0 to 3 with higher scores indicating higher disease severity.
Percentage of Participants With Sustained Mucosal Healing	Week 24, 52	Sustained mucosal healing in participants was defined by achieving mayo endoscopic subscore of 0 or 1 at both Week 24 and Week 52. The mayo endoscopic subscore consisted of the findings of centrally read flexible sigmoidoscopy, graded from 0 to 3 with higher scores indicating higher disease severity.
Percentage of Participants With Mucosal Healing at Week 24 and 52, Among Participants With Mucosal Healing at Baseline	Week 24, 52	Mucosal healing in participants was defined as achieving mayo endoscopic subscore of 0 or 1. The mayo endoscopic subscore consisted of the findings of centrally read flexible sigmoidoscopy, graded from 0 to 3 with higher scores indicating higher disease severity.
Percentage of Participants With Sustained Mucosal Healing, Among Participants With Mucosal Healing at Baseline	Week 24, 52	Sustained mucosal healing in participants was defined by achieving mayo endoscopic subscore of 0 or 1 at both Week 24 and Week 52. The mayo endoscopic subscore consisted of the findings of centrally read flexible sigmoidoscopy, graded from 0 to 3 with higher scores indicating higher disease severity.
Percentage of Participants With Clinical Response at Week 24 and 52	Week 24, 52	Clinical response was defined by a decrease from induction study (A3921094 \[NCT01465763\] or A3921095 \[NCT01458951\]) baseline in Mayo score of at least 3 points and at least 30%, with an accompanying decrease in the rectal bleeding subscore of at least 1 point, or an absolute rectal bleeding subscore of 0 or 1. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity. Percentage of participants with clinical response at Week 24 and 52 have been reported in this outcome measure.
Percentage of Participants With Sustained Clinical Response	Week 24, 52	Sustained clinical response in participants was defined as showing clinical response at both Week 24 and Week 52. Clinical response was defined by a decrease from induction study (A3921094 \[NCT01465763\] or A3921095 \[NCT01458951\]) baseline in mayo score of at least 3 points and at least 30%, with an accompanying decrease in the rectal bleeding subscore of at least 1 point, or an absolute rectal bleeding subscore of 0 or 1. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity. Percentage of participants with sustained clinical response are reported in this outcome measure.
Percentage of Participants in Clinical Remission at Week 24 and 52	Week 24, 52	Clinical remission in participants was defined as a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Percentage of Participants in Sustained Clinical Remission	Week 24, 52	Sustained clinical remission in participants was defined as being in clinical remission at both Week 24 and Week 52. Clinical remission was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Percentage of Participants With Mucosal Healing at Week 52	Week 52	Mucosal healing in participants was defined by mayo endoscopic subscore of 0 or 1. The mayo endoscopic subscore consisted of the findings of centrally read flexible sigmoidoscopy, graded from 0 to 3 with higher subscores indicating higher disease severity.
Percentage of Participants With Sustained Steroid-Free Remission (Defined as Being in Remission and Steroid-Free at Both Week 24 and 52), Among Participants With Remission at Baseline	Week 24, 52	Sustained steroid-free remission was defined by being in remission and steroid-free at both Week 24 and Week 52. Steroid-free remission was defined by being in remission, in addition to no requirement of any treatment with steroid for at least 4 weeks prior to the visit. Remission was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity. Percentage of participants with sustained steroid-free remission (among participants with remission at baseline) were reported in this outcome measure.
Percentage of Participants in Remission at Week 24	Week 24	Remission in participants was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher subscores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Percentage of Participants in Sustained Remission	Week 24, 52	Sustained remission in participants was defined by being in remission at both Week 24 and Week 52. Remission was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher subscores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher score indicating higher disease severity.
Percentage of Participants in Deep Remission at Week 24 and 52	Week 24, 52	Deep remission in participants was defined as a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and 0 subscore for both rectal bleeding and endoscopic subscores. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Percentage of Participants in Sustained Deep Remission	Week 24, 52	Sustained deep remission was defined by being in deep remission at both Week 24 and Week 52. Deep remission in participants was defined as a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and 0 subscore for both rectal bleeding and endoscopic subscores. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Percentage of Participants in Symptomatic Remission at Week 24 and 52	Week 24, 52	Symptomatic remission in participants was defined as a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point, and 0 subscore for both rectal bleeding and stool frequency. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 sub-scores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Percentage of Participants in Sustained Symptomatic Remission	Week 24, 52	Sustained symptomatic remission in participants was defined as being in symptomatic remission at both Week 24 and Week 52. Symptomatic remission was defined as a total Mayo score of 2 points or lower, with no individual subscore exceeding 1 point, and 0 subscore for both rectal bleeding and stool frequency. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Percentage of Participants in Endoscopic Remission at Week 24 and 52	Week 24, 52	Endoscopic remission in participants was defined as a mayo endoscopic subscore of 0. The mayo endoscopic subscore consisted of the findings of centrally read flexible sigmoidoscopy, graded from 0 to 3 with higher subscores indicating higher disease severity.
Percentage of Participants in Sustained Endoscopic Remission	Week 24, 52	Sustained endoscopic remission in participants was defined as being in endoscopic remission at both Week 24 and Week 52. Endoscopic remission was defined by a mayo endoscopic subscore of 0. The mayo endoscopic subscore consisted of the findings of centrally read flexible sigmoidoscopy, graded from 0 to 3 with higher subscores indicating higher disease severity.
Total Mayo Score at Baseline, Week 24 and 52	Baseline, Week 24, 52	Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity.
Change From Baseline in Total Mayo Score at Week 24 and 52	Baseline, Week 24, 52	Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity. Change from baseline in total mayo score at Week 24 and 52 was reported.
Percentage of Participants in Remission, Among Participants With Remission at Baseline	Week 24, 52	Remission in participants was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher score indicating higher disease severity.
Percentage of Participants in Sustained Remission, Among Participants With Remission at Baseline	Week 24, 52	Sustained remission in participants was defined by being in remission at both Week 24 and Week 52. Remission was defined as a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher score indicating higher disease severity.
Percentage of Participants in Steroid-free Remission, Among Participants in Remission at Baseline	Week 24, 52	Steroid-free remission was defined by being in remission, in addition to no requirement of any treatment with steroid for at least 4 weeks prior to the visit. Remission was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity. Percentage of participants in steroid-free remission were reported in this outcome measure.
Percentage of Participants in Steroid-Free Remission, Among Participants Receiving Steroids at Baseline	Week 24, 52	Steroid-free remission was defined by being in remission, in addition to no requirement of any treatment with steroid for at least 4 weeks prior to the visit. Remission was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity. Percentage of participants with steroid-free remission were reported in this outcome measure.
Percentage of Participants in Sustained Steroid-Free Remission, Among Participants Receiving Steroids at Baseline	Week 24, 52	Sustained steroid-free remission was defined by being in remission and steroid-free at both Week 24 and Week 52. Steroid-free remission was defined by being in remission, in addition to no requirement of any treatment with steroid for at least 4 weeks prior to the visit. Remission was defined by a total mayo score of 2 points or lower, with no individual subscore exceeding 1 point and a rectal bleeding subscore of 0. Mayo score was an instrument designed to measure disease activity of UC. It consisted of 4 subscores: stool frequency, rectal bleeding, findings of centrally read flexible sigmoidoscopy and PGA, each graded from 0 to 3 with higher scores indicating higher disease severity. These subscores were summed up to give a total score range of 0 to 12, where higher scores indicating higher disease severity. Percentage of participants with sustained steroid-free remission were reported in this outcome measure.

Trial Locations

Locations (271): Springhill Memorial Hospital (Endoscopy Only)
🇺🇸
Mobile, Alabama, United States
Hope Square Surgical Center
🇺🇸
Rancho Mirage, California, United States
GI Consultants
🇺🇸
Atlanta, Georgia, United States
Citrus Surgery & Endoscopy Center (colonoscopy)
🇺🇸
Crystal River, Florida, United States
Gastroenterology Associates of Central Georgia, LLC
🇺🇸
Macon, Georgia, United States
NYU Langone Long Island Clinical Research Associates
🇺🇸
Great Neck, New York, United States
NYU Langone Nassau Gastroenterology Associates
🇺🇸
Great Neck, New York, United States
Carolina Research, Carolina Digestive Diseases
🇺🇸
Greenville, North Carolina, United States
Cleveland Clinic
🇺🇸
Cleveland, Ohio, United States
Houston Hospital for Specialized Surgery (Endoscopy only)
🇺🇸
Houston, Texas, United States
Baylor College of Medicine - Baylor Medical Center (Drug Storage)
🇺🇸
Houston, Texas, United States
McGovern Medical School -The University of Texas Health Science Center at Houston
🇺🇸
Houston, Texas, United States
Liverpool Hospital
🇦🇺
Liverpool, New South Wales, Australia
Chris Hani Baragwanath Academic Hospital
🇿🇦
Johannesburg, Gauteng, South Africa
Panorama MediClinic
🇿🇦
Cape Town, Western Cape, South Africa
Louis Leipoldt Medical Centre
🇿🇦
Cape Town, Western Cape, South Africa
Kyiv Municipal Clinical Hospital #18, Proctology Department
🇺🇦
Kyiv, Ukraine
SI "Railway Hospital of the SI "Odesa Railway"", Polyclinic Department,
🇺🇦
Odesa, Ukraine
SI "District Clin. Hosp.of Uzhgorod station (STSA "Lviv Railway", Therapy Dep., SBHEI "Uzhgorod Nat.
🇺🇦
Uzhgorod, Ukraine
University of Rochester
🇺🇸
Rochester, New York, United States
Icahn School of Medicine at Mount Sinai
🇺🇸
New York, New York, United States
Chiba University Hospital
🇯🇵
Chiba, Japan
Internal Medicine Center, LLC
🇺🇸
Mobile, Alabama, United States
Citrus Ambulatory Surgery Center
🇺🇸
Orlando, Florida, United States
Internal Medicine Specialists
🇺🇸
Orlando, Florida, United States
Advanced Gastroenterology Center
🇺🇸
Port Orange, Florida, United States
North Florida Gastroenterology Research, LLC
🇺🇸
Orange Park, Florida, United States
San Diego Endoscopy Center
🇺🇸
San Diego, California, United States
Endoscopy Center
🇺🇸
Port Orange, Florida, United States
Port Orange Urgent Care
🇺🇸
Port Orange, Florida, United States
Gastrointestinal Diagnostic Center
🇺🇸
Baltimore, Maryland, United States
Howard County GIDC
🇺🇸
Columbia, Maryland, United States
Saint Joseph Mercy Hospital - Inpatient Pharmacy
🇺🇸
Ann Arbor, Michigan, United States
Surgical Centers of Michigan
🇺🇸
Troy, Michigan, United States
Columbia University Medical Center
🇺🇸
New York, New York, United States
Austin Gastroenterology PA
🇺🇸
Austin, Texas, United States
H-Hartziekenhuis Roeselare-Menen vzw
🇧🇪
Roeselare, Belgium
The Center for Digestive Health
🇺🇸
Milwaukee, Wisconsin, United States
Krajska zdravotni, a.s. Masarykova nemocnice v Usti nad Labem
🇨🇿
Usti nad Labem, Czech Republic
Innomedica OU
🇪🇪
Tallinn, Estonia
East Tallinn Central Hospital Internal Medical Clinic
🇪🇪
Tallinn, Estonia
ECG Unit of West Tallinn Central Hospital
🇪🇪
Tallinn, Estonia
Hopital Saint Antoine - Service de Gastroenterologie
🇫🇷
Paris cedex 12, France
Klinikum Lüneburg/Abteilung Gastroenterologie
🇩🇪
Lüneburg, Germany
Medizinische Hochschule Hannover
🇩🇪
Hannover, Germany
Hopital Nord
🇫🇷
Saint Priest en Jarez, France
Universitätsklinikum Halle
🇩🇪
Halle, Germany
Pannonia Maganorvosi Centrum Kft.
🇭🇺
Budapest, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont
🇭🇺
Pecs, Hungary
Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak
🇭🇺
Budapest, Hungary
Universitaetsklinikum Ulm
🇩🇪
Ulm, Germany
Dr Rethy Pal Korhaz-Rendelointezet, III Belgyogyaszat
🇭🇺
Bekescsaba, Hungary
Karolina Korhaz
🇭🇺
Mosonmagyarovar, Hungary
Debreceni Egyetem Klinikai Kozpont, Belgyogyaszati Intezet Gasztroenterologiai Tanszek
🇭🇺
Debrecen, Hungary
Rabin Medical Center, Beilinson campus
🇮🇱
Petah Tikva, Israel
Kaplan Medical Center
🇮🇱
Rehovot, Israel
Javorszky Odon Korhaz
🇭🇺
Vac, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, I. Sz. Belgyogyaszati Klinika
🇭🇺
Szeged, Hungary
AOR Villa Sofia-Cervello
🇮🇹
Palermo, PA, Italy
Hokkaido P.W.F.A.C Sapporo-Kosei general Hospital
🇯🇵
Sapporo, Hokkaido, Japan
The Hospital of Hyogo College of Medicine
🇯🇵
Nishinomiya, Hyogo, Japan
National Hospital Organization Mito Medical Center
🇯🇵
Higashi-ibaraki-gun, Ibaraki, Japan
Tokyo Medical And Dental University Hospital, Faculty of Medicine
🇯🇵
Bunkyo-ku, Tokyo, Japan
Sameshima Hospital
🇯🇵
Kagoshima-shi, Kagoshima, Japan
Kuniyoshi Hospital
🇯🇵
Kochi-shi, Kochi, Japan
Osaka Medical College Hospital
🇯🇵
Takatsuki-shi, Osaka, Japan
Shiga University of Medical Science Hospital
🇯🇵
Otsu-shi, Shiga, Japan
Toho University Sakura Medical Center
🇯🇵
Chiba, Japan
Kurume University Hospital
🇯🇵
Fukuoka, Japan
Showa University Hospital
🇯🇵
Shinagawa-ku, Tokyo, Japan
KyungHee University Hospital
🇰🇷
Seoul, Republic of Korea, Korea, Republic of
Academic Medical Centre
🇳🇱
Amsterdam, Netherlands
University Medical Center Groningen (UMCG)
🇳🇱
Groningen, Netherlands
Leiden University Medical Center (LUMC)
🇳🇱
Leiden, Netherlands
Shakespeare Specialist Group
🇳🇿
Milford, Auckland, New Zealand
Southern District Health Board
🇳🇿
Dunedin, New Zealand
Waikato Hospital
🇳🇿
Hamilton, New Zealand
H-T. Centrum Medyczne - ENDOTERAPIA
🇵🇱
Tychy, Slaskie, Poland
Pacific Radiology (X-rays only)
🇳🇿
Wellington, New Zealand
Centrum Medyczne Szpital Sw. Rodziny Sp. z o. o.
🇵🇱
Lodz, Iodzkie, Poland
Limited Liability Company Medical Company "Hepatolog"
🇷🇺
Samara, Russian Federation
Oddzial Kliniczny Gastroenterologii Ogólnej i Onkologicznej, Uniwersytecki Szpital
🇵🇱
Lodz, Poland
Nzoz Vivamed
🇵🇱
Warszawa, Poland
Endoskopia Sp. Z O.O.
🇵🇱
Sopot, Poland
Cabinet Particular Policlinic Algomed Srl
🇷🇴
Timisoara, Timis, Romania
Klinika Chorob Wewnetrznych i Gastroenterologii z
🇵🇱
Warszawa, Mazowieckie, Poland
Lexmedica
🇵🇱
Wroclaw, Poland
Gabinet Endoskopii Przewodu Pokarmowego
🇵🇱
Krakow, Poland
Federal state budget institution "State scientific centre of coloproctology"
🇷🇺
Moscow, Russian Federation
Endocare Research Centre
🇿🇦
Western Cape, South Africa
Municipal Budget Institution of Healthcare of Novosibirsk " City Clinical Hospital No 12"
🇷🇺
Novosibirsk, Russian Federation
State Budget Educational Institution of Higher Professional Education
🇷🇺
Novosibirsk, Russian Federation
Federal State Budgetary Institution "Scientific Research Institute of Physiology and Fundamental
🇷🇺
Novosibirsk, Russian Federation
State Budget Institution of Healthcare Nizhniy Novgorod Regional Clinical Hospital named after N. A.
🇷🇺
Nizhniy Novgorod, Russian Federation
Clinical Centre of Serbia, Clinic for Gastroenterology and Hepatology
🇷🇸
Belgrade, Serbia, Europe, Serbia
Military Medical Academy Belgrade
🇷🇸
Belgrade, Serbia
Clinical Centre of Kragujevac
🇷🇸
Kragujevac, Serbia
Clinical Hospital Centre Zvezdara
🇷🇸
Belgrade, Serbia
Federal state Institution "Sibirian regional Medical centre of Federal Medicobiologic Agency",
🇷🇺
Novosibirsk,, Russian Federation
State budget institution of healthcare of Yaroslavl region Regional clinical hospital
🇷🇺
Yaroslavl, Russian Federation
Clinical Centre of Vojvodina, Clinic for Gastroenterology and Hepatology
🇷🇸
Novi Sad, Serbia
Clinical Centre of Vojvodina, Emergency Internal Medicine Division
🇷🇸
Novi Sad, Serbia
"General Hospital ""Djordje Joanovic""
🇷🇸
Zrenjanin, Serbia
Medak s.r.o.
🇸🇰
Bratislava, Slovakia
KM Management spol. s.r.o.
🇸🇰
Nitra, Slovakia
Hospital Clinic i Provincial de Barcelona
🇪🇸
Barcelona, Spain
Internal Medicine Center of Crimean Republic Institution"Clinical Territorial Medical Community"
🇺🇦
Simferopol, Ar Krym, Ukraine
Gastro I., s.r.o.
🇸🇰
Presov, Slovakia
National Taiwan University Hospital
🇨🇳
Taipei City, Taiwan
Dr John Philip Wright
🇿🇦
Claremont, Cape Town, South Africa
Regional Municipal Institution Chernivtsi Regional Clinical Hospital,
🇺🇦
Chernivtsi, Ukraine
Motor-Sich clinic, LLC
🇺🇦
Zaporizhzhia, Ukraine
Vinnytsia Regional Clinical Hospital for Invalids of the Great Patriotic War, Therapy Department #2,
🇺🇦
Vinnytsia, Ukraine
Minicipal Institution City Hospital 7, Therapevtic Department,
🇺🇦
Zaporizhzhia, Ukraine
Addenbrooke's Hospital-Cambridge University Hospitals NHS Foundation Trust
🇬🇧
Cambridge, Cambridgeshire, United Kingdom
Municipal Institution "City Hospital #7", Zaporizhzhia State Medical University
🇺🇦
Zaporizhzhia, Ukraine
UCSD Health System - Investigational Drug Pharmacy - Moores Cancer Center
🇺🇸
La Jolla, California, United States
Department of Gastroenterology, Old Building
🇬🇧
Bristol, England, United Kingdom
Desert Advanced Imaging
🇺🇸
Palm Springs, California, United States
Erik Palmer, DO
🇺🇸
Palm Springs, California, United States
Homan A Zadeh, MD, MPH
🇺🇸
Palm Springs, California, United States
Nature Coast Clinical Research
🇺🇸
Inverness, Florida, United States
Tauranga Hospital
🇳🇿
Tauranga, Bay of Plenty, New Zealand
Hopital Saint Louis - Service d'hepato-gastoenterologie
🇫🇷
Paris, France
Samara Diagnostic center, X-ray Department
🇷🇺
Samara, Russian Federation
Connecticut Clinical Research Foundation
🇺🇸
Bristol, Connecticut, United States
UCSD Medical Center
🇺🇸
La Jolla, California, United States
Alliance Clinical Research
🇺🇸
Oceanside, California, United States
Sharp Rees-Stealy Medical Group, Inc.
🇺🇸
San Diego, California, United States
Sharp Rees-Stealy Medical Group
🇺🇸
San Diego, California, United States
Cotton-O'Neal Clinical Research Center Digestive Health
🇺🇸
Topeka, Kansas, United States
Hopital Saint Andre
🇫🇷
Bordeaux cedex, France
Universitaetsmedizin Berlin, Charite Campus Virchow-Klinikum,
🇩🇪
Berlin, Germany
Gachon University Gil Medical Center
🇰🇷
Incheon, Korea, Republic of
Bowen Hospital
🇳🇿
Wellington, New Zealand
Auckland City Hospital
🇳🇿
Auckland, New Zealand
Hospital Clinico San Carlos
🇪🇸
Madrid, Spain
Municipal Institution of Healthcare City Clinical Hospital 12,
🇷🇺
Saratov, Russia, Russian Federation
Non-State Healthcare Institution "Road Clinical Hospital at the station Samara"
🇷🇺
Samara, Russian Federation
Hospital Universitario de Fuenlabrada
🇪🇸
Madrid, Spain
University College Hospital
🇬🇧
London, Greater London, United Kingdom
Addenbrooke's Hospital
🇬🇧
Cambridge, United Kingdom
Clinical Applications Laboratories, Inc
🇺🇸
San Diego, California, United States
Bristol Hospital
🇺🇸
Bristol, Connecticut, United States
University of California San Francisco
🇺🇸
San Francisco, California, United States
UCSF Endoscopy Unit at Mount Zion
🇺🇸
San Francisco, California, United States
Endoscopy Center of Connecticut, LLC
🇺🇸
Hamden, Connecticut, United States
Gastroenterology Center of Connecticut, PC
🇺🇸
Hamden, Connecticut, United States
Medical Research Center of Connecticut, LLC
🇺🇸
Hamden, Connecticut, United States
Suncoast Endoscopy Center (colonoscopy)
🇺🇸
Inverness, Florida, United States
Central Connecticut Endoscopy Center
🇺🇸
Plainville, Connecticut, United States
Advanced Medical Research Center
🇺🇸
Port Orange, Florida, United States
Florida Medical Clinic, P.A.
🇺🇸
Zephyrhills, Florida, United States
Georgia Endoscopy Center
🇺🇸
Alpharetta, Georgia, United States
Johns Creek Diagnostic Center
🇺🇸
Suwanee, Georgia, United States
Emory Healthcare Heart Center
🇺🇸
Johns Creek, Georgia, United States
Atlanta Gastroenterology Specialists, PC
🇺🇸
Suwanee, Georgia, United States
Digestive Disease Associates, PA
🇺🇸
Catonsville, Maryland, United States
East Ann Arbor Health and Geriatrics Center - UMHS
🇺🇸
Ann Arbor, Michigan, United States
University of Michigan Health Systems
🇺🇸
Ann Arbor, Michigan, United States
Clinical Research Institute of Michigan, LLC
🇺🇸
Chesterfield, Michigan, United States
Medical Science Research Building 1 - UMHS
🇺🇸
Ann Arbor, Michigan, United States
Michigan Clinical Research Unit - UMHS
🇺🇸
Ann Arbor, Michigan, United States
Center for Digestive Health
🇺🇸
Troy, Michigan, United States
Utica Surgery Center (Endoscopy Only)
🇺🇸
Utica, Michigan, United States
Michigan Heart SJMH
🇺🇸
Ypsilanti, Michigan, United States
Saint Joseph Mercy Hospital Outpatient Laboratory
🇺🇸
Ypsilanti, Michigan, United States
Huron Gastroenterology Associates
🇺🇸
Ypsilanti, Michigan, United States
AGA Clinical Research Associates, LLC
🇺🇸
Egg Harbour Township, New Jersey, United States
Mayo Clinic
🇺🇸
Rochester, Minnesota, United States
South Jersey Gastroenterology
🇺🇸
Marlton, New Jersey, United States
Dartmouth Hitchcock Medical Center
🇺🇸
Lebanon, New Hampshire, United States
The Endo Center at Voorhees
🇺🇸
Vorhees, New Jersey, United States
The Private Practice of Simon Lichtiger, MD
🇺🇸
New York, New York, United States
IBD Center - The Mount Sinai Hospital
🇺🇸
New York, New York, United States
CUMC Research Pharmacy
🇺🇸
New York, New York, United States
Kornbluth, Legnani, George MD, PC
🇺🇸
New York, New York, United States
The Endoscopy Center of Lake County
🇺🇸
Mentor, Ohio, United States
Mentor Medical Campus
🇺🇸
Mentor, Ohio, United States
Great Lakes Gastroenterology
🇺🇸
Mentor, Ohio, United States
Professional Quality Research, Inc.- Austin Gastroenterology PA
🇺🇸
Austin, Texas, United States
Regional Gastroenterology Associates of Lancaster, Ltd.
🇺🇸
Lancaster, Pennsylvania, United States
Austin Endoscopy Center II
🇺🇸
Austin, Texas, United States
Baylor College of Medicine (Baylor Medical Center)
🇺🇸
Houston, Texas, United States
Memorial Hermann Hospital
🇺🇸
Houston, Texas, United States
Wasatch Clinical Research
🇺🇸
Salt Lake City, Utah, United States
Digestive Health Specialists of Tyler
🇺🇸
Tyler, Texas, United States
Alpine Medical Group
🇺🇸
Salt Lake City, Utah, United States
Wasatch Endoscopy Center
🇺🇸
Salt Lake City, Utah, United States
VCU Health System Digestive Health Center
🇺🇸
Richmond, Virginia, United States
Concord Repatriation General Hospital
🇦🇺
Concord, New South Wales, Australia
VCU Health System Endoscopy Suite
🇺🇸
Richmond, Virginia, United States
Virginia Commonwealth University
🇺🇸
Richmond, Virginia, United States
Wisconsin Center for Advanced Research
🇺🇸
Milwaukee, Wisconsin, United States
AKH Wien, Universitaetsklinik fuer Innere Medizin III
🇦🇹
Wien, Vienna, Austria
Eastern Health-Box Hill Hospital
🇦🇺
Box Hill, Victoria, Australia
Monash Medical Centre
🇦🇺
Clayton, Victoria, Australia
AZ Groeninge
🇧🇪
Kortrijk, Belgium
GZA St. Vincentius
🇧🇪
Antwerpen, Belgium
UZ Leuven (University Hospital Leuven), Campus Gasthuisberg
🇧🇪
Leuven, Belgium
Hospital de Clinicas de Porto Alegre - HCPA
🇧🇷
Porto Alegre, Rio Grande Do Sul, Brazil
University of Alberta Hospital - Walter C. Mackenzie Health Sciences Centre
🇨🇦
Edmonton, Alberta, Canada
University of Alberta - Zeidler Ledcor Centre
🇨🇦
Edmonton, Alberta, Canada
London Health Sciences Centre - University Hospital
🇨🇦
London, Ontario, Canada
McMaster University Medical Center
🇨🇦
Hamilton, Ontario, Canada
Saskatoon City Hospital
🇨🇦
Saskatoon, Saskatchewan, Canada
Montreal General Hospital - McGill University Health Centre
🇨🇦
Montreal, Quebec, Canada
Instituto de Coloproctología ICO S.A.S.
🇨🇴
Medellin, Antioquia, Colombia
Aarhus University Hospital
🇩🇰
Aarhus C, Denmark
Aalborg Hospital
🇩🇰
Aalborg, Denmark
Bispebjerg Hospital
🇩🇰
Copenhagen NV, Denmark
Odense University Hospital
🇩🇰
Odense C, Denmark
X-Ray Unit, East Tallinn Central Hospital
🇪🇪
Tallinn, Estonia
Hvidovre Hospital
🇩🇰
Hvidovre, Denmark
ECG Unit, Innomedica OU and Qualitas AS (ECG Only)
🇪🇪
Tallinn, Estonia
West Tallinn Central Hospital
🇪🇪
Tallinn, Estonia
X-Ray Department of West Tallinn Central Hospital
🇪🇪
Tallinn, Estonia
X- Ray Department of West Tallinn Central Hospital
🇪🇪
Tallinn, Estonia
Mammograaf OU (Endoscopy Only)
🇪🇪
Tallinn, Estonia
ECG Unit, East Tallinn Central Hospital
🇪🇪
Tallin, Estonia
CHU Amiens PICARDIE - Hopital SUD
🇫🇷
Amiens Cedex 1, France
Hopital Beaujon
🇫🇷
Clichy Cedex, France
Hotel-Dieu CHU Nantes
🇫🇷
Nantes cedex 01, France
C.H.U. de Reims - Hôpital Robert Debré
🇫🇷
Reims cedex, France
Hopital Saint Louis
🇫🇷
Paris, France
Universitaetsklinikum Schleswig-Holstein, Campus Kiel
🇩🇪
Kiel, Schlewig Holstein, Germany
Szent Margit Korhaz - III Belgyogyaszat
🇭🇺
Budapest, Hungary
Peterfy Sandor Utcai Korhaz Rendelointezet es Baleseti Kozpont
🇭🇺
Budapest, Hungary
Gastroenterologische Gemeinschaftspraxis Minden
🇩🇪
Minden, Germany
Bekes Megyei Pandy Kalman Korhaz III. Gasztroenterologiai Osztaly
🇭🇺
Gyula, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
🇭🇺
Miskolc, Hungary
Rambam Health Care Campus
🇮🇱
Haifa, Israel
Istituto Clinico Humanitas IRCSS
🇮🇹
Rozzano, Milano, Italy
AOU Mater Domini - U.O. Fisiopatologia Digestiva
🇮🇹
Catanzaro, Italy
Aichi Medical University Hospital
🇯🇵
Nagakute, Aichi, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵
Minato-ku, Tokyo, Japan
NTT Medical Center Tokyo
🇯🇵
Shinagawa-ku, Tokyo, Japan
National Hospital Organization Sendai Medical Center
🇯🇵
Sendai, Miyagi, Japan
Tokai University Hachioji Hospital
🇯🇵
Hachioji, Tokyo, Japan
Keio University Hospital
🇯🇵
Shinjuku-ku, Tokyo, Japan
Hiroshima University Hospital
🇯🇵
Hiroshima, Japan
Osaka City University Hospital
🇯🇵
Osaka, Japan
Hanyang University Guri Hospital
🇰🇷
Guri-si, Gyeonggi-do, Korea, Republic of
Samsung Medical Center
🇰🇷
Seoul, Korea, Republic of
Seoul National University Hospital,
🇰🇷
Seoul, Korea, Republic of
Digestive Diseases Center GASTRO
🇱🇻
Riga, Latvia
X-Ray Department, Clinic Linezers (radiology only)
🇱🇻
Riga, Latvia
Kyung Hee University Hospital
🇰🇷
Seoul, Korea, Republic of
VU University Medical Center (VUMC)
🇳🇱
Amsterdam, Netherlands
ECG room Clinic Linezers (ECG only) Riga East University Hospital
🇱🇻
Riga, Latvia
P3 Research Limited
🇳🇿
Wellington, New Zealand
Christchurch Hospital
🇳🇿
Christchurch, Canterbury Region, New Zealand
Centrum Endoskopii Zabiegowej, Poradnia Chorob Jelitowych, Szpital Uniwersytecki nr 2 im
🇵🇱
Bydgoszcz, Kujawsko-pomorskie, Poland
Spitalul Universitar de Urgenta Bucharest
🇷🇴
Bucuresti, Romania
Gabinet Lekarski - Janusz Rudzinski
🇵🇱
Bydgoszcz, Poland
Aura SA, s.r.o.
🇸🇰
Nove Mesto nad Vahom, Slovakia
Hospital Universitari de Bellvitge, Servicio de Digestivo
🇪🇸
L'Hospitalet de Llobregat, Barcelona, Spain
Regional Municipal Institution "Chernivtsi Regional Clinical Hospital"
🇺🇦
Chernivtsi, Ukraine
State Institution "Institute of Gastroenterology of the National Academy of Medical Sciences of
🇺🇦
Dniepropetrovsk, Ukraine
State Institution "National L.T. Malaya Therapy Institute of National Academy of
🇺🇦
Kharkiv, Ukraine
Municipal Healthcare Institution Kharkiv City Clinical Hospital #2, Proctology Department
🇺🇦
Kharkiv, Ukraine
LTD "St. Paraskeva Medical Center"
🇺🇦
Lviv, Ukraine
Municipal City Clinical Hospital of the Emergency Medical Care, 1-st Therapy Department of hospital,
🇺🇦
Lviv, Ukraine
Municipal Institution "Odesa Regional Clinical Hospital"
🇺🇦
Odesa, Ukraine
Norfolk and Norwich University Hospital
🇬🇧
Norwich, Norfolk, United Kingdom
NWLH NHS trust
🇬🇧
Harrow, Middlesex, United Kingdom
The North West London Hospitals NHS Trust
🇬🇧
Harrow, Middlesex, United Kingdom
Hepato-Gastroenterologie HK, s.r.o.
🇨🇿
Hradec Kralove, Czech Republic
University Hospital Center Zagreb
🇭🇷
Zagreb, Croatia
Nemocnice Strakonice, a.s., Interni oddeleni
🇨🇿
Strakonice, Czech Republic
Royal University Hospital
🇨🇦
Saskatoon, Saskatchewan, Canada