ACTRN12620001018909Completed未知
nderstanding dyspnoea and exercise limitation in interstitial lung disease: the role of skeletal muscle afferents (sub-study 3)
niversity of Auckland0 sites32 target enrollmentStarted: October 7, 2020Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 32
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Treatment
- Masking
- Open (masking not used)
Eligibility Criteria
- Ages
- 18 Years to o limit (—)
- Sex
- All
Inclusion Criteria
- •Patients with fibrotic ILD (total lung capacity <80% predicted; FEV1/FVC > 0.7 and standard HRCT criteria (British Thoracic Society guidelines, 2008)
- •Control participants free from fibrotic ILD
- •Men and women
- •Aged 18 years or over
Exclusion Criteria
- •More than 10 pack year smoking history
- •Evidence of emphysema on CT scan
- •Pulmonary Sarcoidosis
- •Currently taking regular inhaled therapy for airways disease
- •Serious co-morbidities that may contribute to dyspnoea and/or reduce exercise capacity including:
- •oSevere respiratory disease other than ILD (e.g., chronic obstructive pulmonary disease)
- •oPulmonary hypertension
- •oSevere obesity (Body mass index > 35 kg/m2)
- •oSevere orthopaedic impairment or rheumatologic disease
- •oSignificant neurological disease
- •oInfection or pyrexial illness
- •Presence of any contraindications to cardiopulmonary exercise testing (as per American Thoracic Society/American College of Chest Physicians Statement on Cardiopulmonary Exercise Testing, 2003)
- •oUnstable angina or recent acute myocardial infarction
- •oUncontrolled arrhythmias causing symptoms or haemodynamic compromise
- •oSymptomatic severe aortic stenosis
- •oOxygen saturation <85% at rest on room air
- •oUncontrolled heart failure
- •oUncontrolled asthma
- •oUncontrolled thyroid disorders
- •oMental impairment leading to inability to cooperate
- •Current pregnancy
- •Current users of recreational drugs
- •Current abusers of alcohol
- •Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
- •Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study.
Investigators
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