Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL)
Study Overview
Brief Summary
One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. The presurgical mapping of eloquent areas with functional magnetic resonance imaging (fMRI) is helpful to plan the surgery. BOLD fMRI is now the gold standard to map language areas. However, BOLD signal is diminished near the brain tumor. It is now possible to detect cortical activation with arterial spin labeling (ASL) techniques, detecting variations of perfusion during an activation paradigm (fASL), fASL could be interesting to detect eloquent areas near a brain tumor.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patient 18 years and older
- •Brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery
- •Patient able of accepting protocol information
- •Patient who received information about the protocol and had not expressed its opposition to participate
Exclusion Criteria
- •Patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI
- •Claustrophobic patient
- •Patients who cannot cooperate for the fMRI
- •Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
Outcomes
Primary Outcomes
Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL)
Time Frame: 2 years
Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL) to presurgically detect language areas located near a brain tumor
Secondary Outcomes
- Langage laterality index obtained with both techniques (BOLD fMRI and fASL)and fASL)(2 years)
- Difference of cerebral blood flow maps obtained with ASL and fASL(2 years)