Postural instability and gait disability: related but separable manifestations of Parkinson*s disease - Postural instability versus Gait disability in PD

Radboud Universiteit Nijmegen0 个研究点目标入组 45 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

Trial is onging in other countries

•Parkinson's disease patients
•Men/women of age > 18 years.
•written informed consent
•idiopathic PD, according to the UK Brain Bank Criteria.
•disease severity 2.5, 3 or 4 on the Hoehn & Yahr scale (gait and/or balance disorders but still able to walk/stand independently.;Controls
•right-handed men/women of age > 18 years
•written informed consent

•Parkinson disease patients
•patients with levodopa*induced gait or balance disorders (e.g., levodopa*induced freezing of gait). We will therefore exclude patients who score greater on levodopa than off levodopa on the gait, balance or freezing items of the UPDRS.
•failure to lay still for 90 minutes in the scanner (for example due to head tremor or medication-induced excessive movement)
•failure to stand/walk independently
•other causes of clinically relevant gait difficulties (eg, orthopedic or vestibular disorders)
•contra*indications for MR scanning (eg, clautrophobia)
•other neurological disorders such as stroke in history or a psychiatric disease
•depression
•cognitive impairment (MMSE <26).
•severe comorbidity (eg cancer)
•pregnancy
•poor eyesight;Controls
•failure to lay still for 90 minutes in the scanner (for example due to head tremor or medication-induced excessive movement)
•failure to stand/walk independently
•causes of clinically relevant gait/balance difficulties (eg, orthopedic or vestibular disorders)
•contra*indications for MR scanning (eg, claustrophobia).
•any neurological disorders such as stroke in history or a psychiatric disease
•depression
•cognitive impairment (MMSE <26).
•severe comorbidity (eg cancer)
•pregnancy
•poor eyesight

发起方