Markers of Airway Inflammation in BAL Fluid From Children With Asthma
Completed
- Conditions
- Asthma
- Registration Number
- NCT00838552
- Lead Sponsor
- National Jewish Health
- Brief Summary
The study compares the biochemical markers in bronchoalveolar lavage samples from asthmatic children to those markers found in non-asthmatic children with other respiratory diseases. The investigators hypothesize that certain markers will be associated specifically with asthma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 103
Inclusion Criteria
- 18 years of age or younger
- Scheduled for bronchoscopy at National Jewish Health for persistent asthma, persistent, poorly controlled wheezing, chronic cough, GERD, atelectasis, bronchopulmonary dysplasia, infection.
- Consent and assent from parent and patient [if appropriate].
Exclusion Criteria
- Unwillingness to consent/assent to retrieval of BAL fluid for research analysis.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The measurement of levels of lipopolysaccharides [LPS], which mediates airway inflammation, in bronchoalveolar lavage [BAL] fluid from children with asthma and comparison to LPS levels in children with non-asthma respiratory diseases Single time point
- Secondary Outcome Measures
Name Time Method Characterization of the inflammatory cytokine and chemokine profiles in bronchoalveolar lavage [BAL] fluid in children with asthma and comparison to the profile for children with non-asthma respiratory diseases. Single time point
Trial Locations
- Locations (1)
National Jewish Health
🇺🇸Denver, Colorado, United States