Hypertension, Small Vessel Disease (SVD) and cognitive function.

Completed

Conditions: 10057166
10009841
hypertension related. silent brain damage due to elevated blood pressures
silent cerebrovascular disease
10007963

Registration Number: NL-OMON39508

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 112

Inclusion Criteria

Inclusion criteria
- Patients who participated in the HYBRiD- study
- Consent for being contacted for follow-up studies
- Essential hypertension:
o Use of antihypertensive medication at first visit of the hypertension clinic, or
o Office blood pressure: *140 and/ or *90 mmHg (average of 3 measurements with intervals of 2 minutes minimum, or
o ABPM blood pressure: *125 and/ or *80 mmHg (average of 24 hours).
- Caucasian
- Age between 18 and 90 years
- Ambulant

Exclusion Criteria

- - Cerebrovascular abnormalities in anamnesis
o TIA in 6 months before anamnesis
o Brain infarction
o Haemorrhage (subarachnoid or intracerebral)
- Contra indications for MRI
o Heart valve prosthesis
o Pacemaker
o Intracerebral clips (aneurysm)
o Intra-ocular metal pieces
o Cochlear implant
o Claustrophobia
- When the patient does not appreciate to receive the results of the study, in particular if abnormalities are found during MRI or neuropsychological assessment, which are of great importance for the patients health.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The degree of SVD (WMLs, LACIs, and BMBs) and cognitive functioning. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Haptoglobin polymorphism and EPC-activity.<br /><br>Other cerebral abnormalities observed by MRI: atrophy and other cerebral<br /><br>abnormalities. </p><br>