Antibiotic treatment following surgical drainage of perianal abscess: a double-blind, placebo-controlled, randomized trial

ZonMw0 个研究点目标入组 298 人开始时间: 2021年3月26日最近更新: 2024年3月4日

试验速览

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•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•-Men and women aged 18 years or older
•-Eligible for e-mail questionnaires
•-Sufficient understanding of the Dutch written language (reading and writing)
•-Obtained written informed consent
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 298
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•-A coexistent perianal fistula
•-Spontaneous drainage
•-Secondary or recurrent perianal abscess
•-Presence of an internal fistula opening
•-Any additional surgical procedure performed during the same session
•-Previous (peri)anal surgery
•-Inflammatory bowel disease
•-History of radiation of the pelvic area
•-Anorectal malignancy
•-Immunodeficiency
•- Kidney failure, eGFR <30ml/min
•-Valvular heart disease
•-Pregnancy or lactation
•-Antibiotic prophylaxis indicated for another reason
•-Immunosuppressive medication at the time of surgery
•-Allergy to metronidazole or ciprofloxacin
•- Not able or trouble with swallowing pills
•-Concomitant use of: tizadine, theopylline clozapine, olanzapine, pirfenidone, carbamazepine, agomelatine, amiodarone, erytromcyine, sotalol, azithormycine, citalopram, escitalopram, flecainide, fluconazol, haloperidol >5mg/day, methadone, ondansetron, lithium, lopinavir/ritonavir, ritonavir capsules, temsirolimus, disulfiram, mebendazole, corticosteroids

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