Influence of Exercise on the Mobility and Balance of Individuals With Multiple Sclerosis Influence of High-Dosage Physical Therapy on the Balance and Mobility of Individuals With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Changes in Balance Using the Sensory Organization Test
研究概览
简要总结
Outcomes from the investigators' recent investigation suggested that a high dosage of challenging physical therapy exercises can result in clinically improvements in the postural balance and walking speed of individuals with MS.
This investigation will evaluate mobility and postural balance improvements in individuals with MS who participate in a therapeutic protocol consisting of activity based exercises, and in individuals with MS that participate in challenging physical therapy protocol.
详细描述
Background: Outcomes from the investigators' recent exploratory investigation suggested that a high dosage of challenging physical therapy exercises can result in clinically relevant improvements in the postural balance and walking speed of individuals with MS.
Objective
The investigators anticipated that the promising results were due to the novel challenging postural balance and mobility exercises. The purpose of this investigation was to test this notion by evaluating the mobility and postural balance improvements that could be achieved in a cohort of individuals with MS who participated in a therapeutic protocol that consisted of activity based exercises, and a cohort of individuals with MS that participated in the challenging physical therapy protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Definitive diagnosis of multiple sclerosis
- •Kurtzke Expanded Disability Status of 3.0 - 6.5
- •Able to walk on a treadmill at a minimum of 0.5 miles per hour while holding onto handrails
- •Cognitively and emotionally competent
- •A Mini-Mental State Examination score > 21
- •Composite score on the computerized Sensory Organization Test of < 70
排除标准
- •Documented MS-related relapse in the previous 6 months
- •Major MS-specific medication changes within the previous 3 months
- •Presence of another major co-morbidity such as neurological disorders, uncontrolled pain, hypertension, and diabetes
研究组 & 干预措施
Therapeutic Challenge Group
The Therapeutic Challenge Group will complete the Therapeutic Challenge Program twice a day, five days each week for 6 weeks.
干预措施: Therapeutic Challenge Program (Behavioral)
Therapeutic Exercise Group
The Therapeutic Exercise Group will complete the Therapeutic Exercise Program twice a day, five days each week for 6 weeks.
干预措施: Therapeutic Exercise Program (Behavioral)
结局指标
主要结局
Changes in Balance Using the Sensory Organization Test
时间窗: Baseline and 6 weeks
The Sensory Organization Test consists of six different conditions that measure each subject's ability to integrate visual, somatosensory, and vestibular feedback to reduce the overall amount of postural sway and improve balance.
Changes in Walking Velocity, Step Lengths, Step Widths, and Cadence
时间窗: Baseline and 6 weeks
The changes in walking velocity, step lengths, step widths, and cadence will be quantified using a GaitRITE digital mat.
次要结局
- Changes in Endurance using the 6-Minute Walk(Baseline and 6 weeks)