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Clinical Trials/NCT00714987
NCT00714987WithdrawnNot Applicable

Predictive Value of the Extra-Vascular Lung Water (EVLW) for the Alveolar Recruitment in the Acute Respiratory Distress Syndrome ( ARDS ).

University Hospital, Strasbourg, France0 sites40 target enrollmentStarted: January 2009Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Withdrawn
Sponsor
Enrollment
40
Primary Endpoint
Estimate the Lung Water Extra-Vascular as predictive marker of the answer (Variation of needs in oxygen) to the ventilatory strategy: the low level, and high level of pressure positive expiratory, in the SDRA
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

  • ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
  • The set of the PEEP (low or high levels) remains unclear : it seems that some patients need low levels of PEEP whereas anther need high levels; but there is no validated data that can discriminate them.
  • We hypothesized that patients with low levels of EVLW ( measured with the Picco® system ) need low level of PEEP to ameliorate their oxygenation ( measured with the PaO2/FiO2 ratio ) whereas patients with high levels of EVLW) need high levels of PEEP.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •ARDS criteria.

Exclusion Criteria

  • •severe pulmonary hypertension;
  • •chronic right ventricular failure;
  • •pulmonary embolism;
  • •tricuspidian valvulopathy;
  • •history of spontaneous pneumothorax;
  • •severe emphysema;
  • •bronchomalacia;
  • •recent pulmonary surgery;
  • •Interstitial pulmonary fibrosis;
  • •End of life;
  • •Chronic neuromyopathie;
  • •Recent neurosurgery or intracranian hypertension;
  • •Pregnancy.

Outcomes

Primary Outcomes

Estimate the Lung Water Extra-Vascular as predictive marker of the answer (Variation of needs in oxygen) to the ventilatory strategy: the low level, and high level of pressure positive expiratory, in the SDRA

Time Frame: During all the period of stay of the patient Intensive care unit

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
University Hospital, Strasbourg, France
Sponsor Class
Other

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