Predictive Value of the Extra-Vascular Lung Water (EVLW) for the Alveolar Recruitment in the Acute Respiratory Distress Syndrome ( ARDS ).

University Hospital, Strasbourg, France0 sites40 target enrollmentJanuary 2009

ConditionsAcute Respiratory Distress Syndrome

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Acute Respiratory Distress Syndrome
Sponsor: University Hospital, Strasbourg, France
Enrollment: 40
Primary Endpoint: Estimate the Lung Water Extra-Vascular as predictive marker of the answer (Variation of needs in oxygen) to the ventilatory strategy: the low level, and high level of pressure positive expiratory, in the SDRA
Status: Withdrawn
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
The set of the PEEP (low or high levels) remains unclear : it seems that some patients need low levels of PEEP whereas anther need high levels; but there is no validated data that can discriminate them.
We hypothesized that patients with low levels of EVLW ( measured with the Picco® system ) need low level of PEEP to ameliorate their oxygenation ( measured with the PaO2/FiO2 ratio ) whereas patients with high levels of EVLW) need high levels of PEEP.

Registry

clinicaltrials.gov

Start Date

January 2009

End Date

February 2009

Last Updated

16 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Strasbourg, France

Eligibility Criteria

Inclusion Criteria

•ARDS criteria.

Exclusion Criteria

•severe pulmonary hypertension;
•chronic right ventricular failure;
•pulmonary embolism;
•tricuspidian valvulopathy;
•history of spontaneous pneumothorax;
•severe emphysema;
•bronchomalacia;
•recent pulmonary surgery;
•Interstitial pulmonary fibrosis;
•End of life;

Outcomes

Primary Outcomes

Estimate the Lung Water Extra-Vascular as predictive marker of the answer (Variation of needs in oxygen) to the ventilatory strategy: the low level, and high level of pressure positive expiratory, in the SDRA

Time Frame: During all the period of stay of the patient Intensive care unit