Circulating PRCP in STEMI Patients Undergoing Primary PCI

Completed

• Conditions: Percutaneous Coronary Intervention; PRCP; Myocardial Infarction
• Interventions: Procedure: Primary PCI

• Registration Number: NCT02772133
• Lead Sponsor: Qilu Hospital of Shandong University

Brief Summary

Purpose: The purpose of this study is to evaluate the impact of acute ST-segment elevation myocardial infarction (STEMI) and primary percutaneous coronary intervention (PCI) on circulating prolylcarboxypeptidase (PRCP) level and activity.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05
• Study First Submitted: 2016-05-09
• Study First Submitted QC: 2016-05-10
• Study First Posted: 2016-05-13
• Primary Completion: 2016-07
• Study Completion: 2016-07
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-31
• Last Update Posted: 2020-01-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 275

Inclusion Criteria

• Admitted for primary PCI for STEMI involving the LAD within 12 hours of onset of symptoms. STEMI will be defined as typical ECG changes (ST segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes;
• Age ≥18 years;
• Informed consent from subject or next of kin.

Exclusion Criteria

• Nonischaemic Cardiomyopathy;
• Cardiac surgery planed in the 6 months;
• Mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation);
• Renal or hepatic failure;
• Malignancy, HIV, or central nervous system disorder;
• Cardiopulmonary resuscitation >15 min and compromised level of consciousness;
• Cardiogenic shock;
• Current participation in any research study involving investigational drugs or devices;
• No written consensus;
• Previous myocardial infarction.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
STEMI patients	Primary PCI	-

Primary Outcome Measures

Name	Time	Method
Circulating PRCP level	1 month
Circulating PRCP activity	1 month

Secondary Outcome Measures

Name	Time	Method
Circulating Ang II level	1 month
Circulating Ang-(1-7) level	1 month
Circulating BK-(1-9) level	1 month
Circulating KBK-(1-9) level	1 month

Trial Locations

Locations (4)

Qianfoshan Hospital, Shandong University; 🇨🇳 Jinan, Shandong, China

Shandong University Qilu Hospital; 🇨🇳 Jinan, Shandong, China

Jinan Central Hospital, Shandong University; 🇨🇳 Jinan, Shandong, China

Shandong Provincial Hospital, Shandong University; 🇨🇳 Jinan, Shandong, China