NCT02772133已完成不适用
Circulating PRCP in STEMI Patients Undergoing Primary PCI
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 275
- 试验地点
- 4
- 主要终点
- Circulating PRCP level
研究概览
简要总结
Purpose: The purpose of this study is to evaluate the impact of acute ST-segment elevation myocardial infarction (STEMI) and primary percutaneous coronary intervention (PCI) on circulating prolylcarboxypeptidase (PRCP) level and activity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Admitted for primary PCI for STEMI involving the LAD within 12 hours of onset of symptoms. STEMI will be defined as typical ECG changes (ST segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes;
- •Age ≥18 years;
- •Informed consent from subject or next of kin.
排除标准
- •Nonischaemic Cardiomyopathy;
- •Cardiac surgery planed in the 6 months;
- •Mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation);
- •Renal or hepatic failure;
- •Malignancy, HIV, or central nervous system disorder;
- •Cardiopulmonary resuscitation >15 min and compromised level of consciousness;
- •Cardiogenic shock;
- •Current participation in any research study involving investigational drugs or devices;
- •No written consensus;
- •Previous myocardial infarction.
结局指标
主要结局
Circulating PRCP level
时间窗: 1 month
Circulating PRCP activity
时间窗: 1 month
次要结局
- Circulating BK-(1-9) level(1 month)
- Circulating KBK-(1-9) level(1 month)
- Circulating Ang II level(1 month)
- Circulating Ang-(1-7) level(1 month)
研究者
Pan-Pan Hao
MD, PhD
Qilu Hospital of Shandong University
研究点 (4)
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