The importance of non-essential amino acids for maintaining skeletal muscle protein synthesis rates in healthy young me

• Conditions: muscle anabolism; Muscle growth; 10028302

• Registration Number: NL-OMON53839
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 64

Inclusion Criteria

• Male
• Age between 18 and 35 y inclusive
• BMI between 22 and 30 kg/m2
• Non-smoker
• Having given informed consent

Exclusion Criteria

• Participating in a structured (progressive) exercise program
• Smoker
• Diagnosed GI tract disorders or diseases
• Diagnosed musculoskeletal disorders
• Diagnosed metabolic disorders (e.g. diabetes)
• Cardiovascular disease
• Hypertension (blood pressure above 140/90 mmHg)
• Donated blood 3 months prior to test day
• Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories).
• Chronic use of gastric acid suppressing medication
• Chronic use of anti-coagulants
• Any intolerance to foods included in the standardized diet intervention

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Skeletal muscle protein synthesis rates</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Skin protein synthesis rates<br /><br>- Muscle mass<br /><br>- Resting energy expenditure<br /><br>- Blood pressure and heart rate<br /><br>- Plasma profiles (lipids, insulin, amino acids, inflammatory markers)<br /><br>- Urine markers of protein breakdown<br /><br>- Skeletal muscle mitochondrial respiration<br /><br>- Organ volumes<br /><br>- Biochemical signaling pathways in skeletal muscle</p><br>