Surface Mechanomyography Using a Parasternal Patch to Measure and Detect Respiratory Drive and Effort

Not Applicable

Completed

• Conditions: Acute Respiratory Failure

• Registration Number: NCT06046898
• Lead Sponsor: University Hospital, Angers

Brief Summary

Surface mechanomyography (sMMG) has been proposed as a tool to study muscle mechanical activity. sMMG is a noninvasive technique using specific transducers to record muscle surface oscillations due to mechanical activity of the motor units . It could be of major interest for the detection of respiratory efforts in patients with respiratory failure. This study aims at assessing the performances of sMMG to measure and detect respiratory drive and effort in healthy volunteers.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-08-31
• Study First Submitted QC: 2023-09-18
• Study First Posted: 2023-09-21
• Study Start: 2023-11-06
• Primary Completion: 2024-06-26
• Study Completion: 2024-06-26
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-26
• Last Update Posted: 2025-03-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• healthy volunteer
• Age > 18 and < 60
• Informed consent
• Fasting
• Subjects covered by or having the rights to medical care assurance

Exclusion Criteria

• Obesity (BMI > 30 kg.m-2)
• Respiratory disease
• Cardiovascular disease
• Contraindication to the insertion of a nasogastric tube
• Incapacity to consent
• Pregnancy, breastfeeding
• Bad understanding of the French language,
• Other protected person according to articles L1121.7 and L1121.8 of the French Public Health Act.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Accuracy of sMMG to detect respiratory effort	5 minutes after the beginning of recording	Delays between the beginning of the respiratory effort detected by sMMG and Eadi and the end of the respiratory effort detected by sMMG and Eadi (msec)

Secondary Outcome Measures

Name	Time	Method
Comparison between sMMG slope & Eadi parameters	5 minutes after the beginning of recording	Accuracy of sMMG to assess the intensity of respiratory drive (in comparison with Eadi in microvolt)
Comparison between sMMG slope & slope Peso	5 minutes after the beginning of recording	Accuracy of sMMG to assess the intensity of respiratory drive (in comparison Peso in cm H20)
Delay between neural time measured by sMMG and neural time measured by Eadi	5 minutes after the beginning of recording	Accuracy of sMMG to assess the duration of inspiratory neural time (in comparison with Eadi in msec)
Comparison between sMMG-time (MMG-TP) and PTPes-Pes Peak	5 minutes after the beginning of recording	Accuracy of sMMG to assess the intensity of respiratory effort (in comparison with pressure-time product in cm H2O.s.min-1)

Trial Locations

Locations (1)

Angers University Hospital; 🇫🇷 Angers, France