Mentalization - Based Treatment: Adolescents With Co-morbid Depression and Personality Disorder

Not Applicable

• Conditions: Personality Disorder; Depression
• Interventions: Other: MBT; Other: treatment as usual

• Registration Number: NCT01204346
• Lead Sponsor: North East London Foundation Trust

Brief Summary

Mentalisation based treatment (MBT) for young people with co-morbid depression and emerging personality disorder will be more effective in a day/inpatient setting than treatment as usual.

Detailed Description

Systematic literature review on outcomes with young people with depression and emerging personality disorder showed clear evidence that this group of young people are severely hampered and adult outcomes are strongly linked to both adult PD as well as adult psychiatric disturbance and lower levels of adult functioning. (Crawford et al, 2008; Kasen et al, 1999; Kasen et al, 2007; Lewinsohn et al, 1999) This argues very clearly for the need to diagnose young people presenting with co-morbid depression and emerging personality disorder in order to intervene and help these young people's struggles as it will prevent poor prognostic adult outcomes. There were no treatment programs that specifically focussed on the treatment of this co-morbid group in the literature. Several studies focussed on the treatment of depression alone and only one RCT focussed on the treatment of adolescent personality disorder (Chanen et al, 2007). In adult studies mentalization-based treatment programs were found to be effective ( as well as cost effective) in a day hospital setting for adults with personality disorder and depression (Bateman, et al, 2007) This study aims to conduct a control trial to test whether MBT will be more effective than TAU in this group. All cases will be tested on admission, at discharge and followed up at 2 years post discharge.

Study Timeline

• Study First Submitted: 2010-09-16
• Study First Submitted QC: 2010-09-16
• Study First Posted: 2010-09-17
• Study Start: 2010-12
• Status Verified: 2011-07
• Last Update Submitted: 2014-10-02
• Last Update Posted: 2014-10-03
• Primary Completion: 2016-12
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• all young people who are admitted to Brookside adolescent unit between the ages 12 - 17 presenting with depression and emerging personality disorder will be eligible

Exclusion Criteria

• Young people with autistic spectrum disorders or severe learning disabilities.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MBT group	MBT	mentalization based treatment program
Treatment as usual group	treatment as usual	treatment as usual group

Primary Outcome Measures

Name	Time	Method
Global assessment of functioning	within 1 week of admission	measures level of functioning
global assessment of functioning	Average of 8 weeks	measures level of functioning

Secondary Outcome Measures

Name	Time	Method
mood and feelings questionnaire	At average of 8 weeks	Assesses mood in terms of number of depressive symptoms
Mood and feelings questionnaire	Within 1 week of admission	Assesses mood in terms of number of depressive symptoms

Trial Locations

Locations (1)

North East London Foundation Trust; 🇬🇧 Ilford, Essex, United Kingdom