Clinical Decision Support for Blood Transfusions to Improve Guideline Adherence

Not Applicable

Completed

• Conditions: Hypofibrinogenemia; Thrombocytopenia; Coagulopathy, Mild; Anemia
• Interventions: Behavioral: Clinical Decision Support

• Registration Number: NCT05634005
• Lead Sponsor: University of Utah

Brief Summary

Determine whether clinical decision support (best practice advisory) improves provider adherence to transfusion guidelines for all four major blood components (red blood cells, plasma, platelets, and cryoprecipitate) using a randomized study design to reduce risk of bias. Alerts will be visible to the experimental ordering provider group, while they will not be visible to the control. Both groups still have access to information about best practices: local clinical transfusion guidelines are available and education on blood transfusion best practices will continue regardless of randomization assignment.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-10-17
• Study First Submitted QC: 2022-11-21
• Study First Posted: 2022-12-01
• Study Start: 2023-02-01
• Primary Completion: 2024-02-01
• Study Completion: 2024-02-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-03
• Last Update Posted: 2025-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1543

Inclusion Criteria

• Ordering providers that order at least one blood product in the electronic health record

Exclusion Criteria

• Any individual without privileges to place an initial order for blood product(s)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ordering Providers Assigned to Visible Clinical Decision Support Alerts	Clinical Decision Support	Clinical decision support alert will fire and become visible to the ordering provider in the electronic health record if blood product(s) are ordered out of accordance with guidelines. Information about transfusion guidelines and best practices will be sent to providers prior to starting the study and will be available on an internal website.

Primary Outcome Measures

Name	Time	Method
Number of blood components transfused that met clinical decision support alert criteria	Through study completion, an average of 12 months	Number of blood components transfused (includes red blood cell, platelet, plasma, and cryoprecipitate pools) that met criteria for clinical decision support alerts to fire

Secondary Outcome Measures

Name	Time	Method
Number of plasma components transfused that met clinical decision support alert criteria	Through study completion, an average of 12 months	Number of plasma components transfused that met criteria for clinical decision support alerts to fire
Number of cryoprecipitate component pools transfused that met clinical decision support alert criteria	Through study completion, an average of 12 months	Number of cryoprecipitate component pools transfused that met criteria for clinical decision support alerts to fire
Number of red blood cell components transfused that met clinical decision support alert criteria	Through study completion, an average of 12 months	Number of red blood cell components transfused that met criteria for clinical decision support alerts to fire
Number of platelet components transfused that met clinical decision support alert criteria	Through study completion, an average of 12 months	Number of platelet components transfused that met criteria for clinical decision support alerts to fire

Trial Locations

Locations (1)

University of Utah; 🇺🇸 Salt Lake City, Utah, United States