Are there differences in central nervous system processing in patients with refractory chronic cough?

Wythenshawe Hospital Research and Development Directorate0 个研究点目标入组 74 人开始时间: 2018年12月10日最近更新: 2024年7月8日

适应症

试验速览

暂无简介。

•1. Males and females 18-80 years, inclusive
•2. Non-smokers >6 months; ex-smokers <20 pack years
•Healthy Volunteers
•3. No clinically relevant abnormalities based on the medical history, physical examination, vital signs
•4. No history of current or significant past respiratory disease, specifically a diagnosis of asthma
•5. Spirometry within normal limits
•Chronic Cough Patients
•6. Have a refractory chronic cough as defined by BTS guidelines
•7. No evidence of asthma

•1. Routine contraindications to fMRI scanning e.g. certain metal implants, recent surgery, extreme claustrophobia etc
•2. Any condition that may increase airway/circulating levels of ATP/adenosine e.g. chronic cardiac failure, chronic hypoxia, vigorous exercise within 48 hours
•3. Pregnant or breastfeeding
•4. Upper or lower respiratory tract infection or significant change in pulmonary status within 4 weeks of enrolment
•5. Any therapy that may modulate cough (e.g. ACE inhibitors, opioids, gabapentin). Patients can be included if they are willing/able to discontinue these for the study duration and a suitable washout period

发起方

Wythenshawe Hospital Research and Development Directorate