Are there differences in central nervous system processing in patients with refractory chronic cough?

Wythenshawe Hospital Research and Development Directorate0 sites74 target enrollmentDecember 10, 2018

Overview

No summary available.

Registry

who.int

Start Date

December 10, 2018

End Date

September 9, 2022

Last Updated

last year

Study Type

Observational

Sex

All

Sponsor

Wythenshawe Hospital Research and Development Directorate

•1\. Males and females 18\-80 years, inclusive
•2\. Non\-smokers \>6 months; ex\-smokers \<20 pack years
•Healthy Volunteers
•3\. No clinically relevant abnormalities based on the medical history, physical examination, vital signs
•4\. No history of current or significant past respiratory disease, specifically a diagnosis of asthma
•5\. Spirometry within normal limits
•Chronic Cough Patients
•6\. Have a refractory chronic cough as defined by BTS guidelines
•7\. No evidence of asthma

•1\. Routine contraindications to fMRI scanning e.g. certain metal implants, recent surgery, extreme claustrophobia etc
•2\. Any condition that may increase airway/circulating levels of ATP/adenosine e.g. chronic cardiac failure, chronic hypoxia, vigorous exercise within 48 hours
•3\. Pregnant or breastfeeding
•4\. Upper or lower respiratory tract infection or significant change in pulmonary status within 4 weeks of enrolment
•5\. Any therapy that may modulate cough (e.g. ACE inhibitors, opioids, gabapentin). Patients can be included if they are willing/able to discontinue these for the study duration and a suitable washout period