Analysis of pharmacokinetic and microbiologic properties associated with vancomycin treatment failure in methicillin-resistant Staphylococcus aureus bacteremia

Not Applicable

Completed

• Conditions: Certain infectious and parasitic diseases

• Registration Number: KCT0001315
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 117

Inclusion Criteria

All adult patients (aged =18 years)had blood culture result during the study period at Seoul National University Bundang Hospital (a 900-bed tertiary hospital in Seongnam) and Seoul National University Hospital (a 1,300-bed tertiary hospital in Seoul).

Exclusion Criteria

Patients who had the following criteria are excluded: (1) polymicrobial bacteremia; (2) immediately transferred to other hospital; (3) no data on treatment outcome; (4) died within 72 hours after index culture; (5) received renal replacement therapy; (6) received vancomycin for less than 72 hours; (7) not receiving vancomycin within 5 days after index culture; (8) vancomycin serum concentration was not checked within the first 5 days of therapy; (9) unavailable index MRSA isolate.

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vancomycin treatment failure was defined as one of the following criteria : (1) 30-day all-cause mortality, (2) persistent bacteremia (>=7 days of vancomycin) (3) recurrence of bacteremia (<=30 days);initial steady-state vancomycin AUC24/MIC

Secondary Outcome Measures

Name	Time	Method
vancomycin MIC;vancomycin trough level