Effect of whey protein-enriched enteral nutrition in addition to standardized exercise training on the PREServation of MUScle function in critically ill patients: a randomized controlled trial - PRESMUS study

Vrije Universiteit Medisch Centrum0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Admitted to the intensive care unit; Age >= 18 years; On mechanical ventilation and expected to be mechanically ventilated for more than 72 hours after initiation of study; Expected to tolerate enteral nutrition and to require enteral nutrition for more than 72 hours; SOFA score >= 6 on admission day; Written informed consent of patient or legal representative.

•Contra-indication to enteral nutrition; Short bowel syndrome; Child C liver cirrhosis or acute liver failure; Dialysis dependency; Requiring other specific enteral nutrition for medical reason; BMI > 35 kg/m2; Extensive treatment limitations; Disseminated malignancy; Haematological malignancy; Primary neuromuscular pathology; Chronic use of corticosteroids for > 7 days before ICU admission; Contra-indication for muscle biopsy (need for uninterrupted systemic anticoagulation, PT >1.4 , Thrombocytes <100).

发起方