Genome-wide case-control association study to identify susceptibility gene to diabetic nephropathy using single nucleotide polymorphisms.
Not Applicable
- Conditions
- Diabetic nephropathy
- Registration Number
- JPRN-C000000272
- Lead Sponsor
- RIKE
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Sex
- All
- Target Recruitment
- 2000
Inclusion Criteria
Not provided
Exclusion Criteria
Patients with other chronic renal diseases.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diabetic patients with diabetic retinopathy were divided into two groups: 1) nephropathy cases (DN):-patients with overt nephropathy, 2) controls (C):-patients showing no evidence of renal dysfunction (based on the urinary albumin levels). Our first screening involved genotyping 94 DNs and 94 Cs for 10,000 SNP loci, and we further analyzed the SNP loci showing significant differences in allelic frequencies between DN and C using a larger number of patients.
- Secondary Outcome Measures
Name Time Method