Comparison of Morning or Evening Antihypertensive Drugs on Albuminuria (The MORE trial): A Randomized Control Trial

avamindradhiraj University, Thailand0 个研究点目标入组 58 人开始时间: 2022年7月22日最近更新: 2024年8月19日

适应症

试验速览

Treatment of hypertension with either morning or evening dose regimen did not impact UACR or reduce blood pressure

•Age 18-80 year
•Hypertension for more than 1 year
•At least one antihypertensive agent for more than 3 months and at least one antihypertensive agent in Angiotensin-converting enzyme inhibitor (ACEI) and/or Angiotensin receptor blocker (ARB)
•Well controlled blood pressure (systolic blood pressure < 150 mmHg, Diastolic blood pressure < 90 mmHg)
•albuminuria > 30 mg/g
•Renal function (estimated glomerular filtration rate, eGFR > 15 ml/min/1.73 m2)

•End stage kidney disease
•Poor control blood pressure
•Severe comorbid disease for example congestive heart failure, active cancer
•Inflammatory disease or active infection for example arthritis, pyelonephritis
•Study termination criteria
•Flare of comorbid disease or active infection (Cancer, acute coronary syndrome or any underlying disease that effect renal function) after included in study

发起方

avamindradhiraj University, Thailand