Ovarian Reserve in Patients With Type 1 Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- antral follicle count
研究概览
简要总结
Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. Hyperglycemic condition in diabetes can cause organ damage. This study aims to measure serum hormones including FSH, LH, E2, AMH, ovarian volume and antral follicle count (indicators of ovarian reserve) in women with and without type 1 diabetes mellitus.
详细描述
Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. It is showed that hyperglycemic state in diabetes results in organ damage like kidneys and eyes. Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients diagnosed with type 1 diabetes mellitus and to compare them to healthy controls. Serum FSH, LH, E2 and AMH will be measured on the 3rd day of the cycle. Antral follicle count and ovarian volume measurement will be done with ultrasonography. Ovarian reserve markers will be compared between the groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Reproductive age group women: 18-40 years
- •Women diagnosed with type 1 diabetes (case group)
- •Women without type 1 diabetes (control group)
排除标准
- •Women with PCOS (polycystic ovary syndrome)
- •history of ovarian surgery
- •Body mass index (BMI) over 30
结局指标
主要结局
antral follicle count
时间窗: during procedure
antral follicles of ovaries will be counted with ultrasonography
E2, FSH, LH, AMH levels
时间窗: during procedure
E2, FSH, LH, AMH levels of blood samples will be measured
ovarian volume
时间窗: during procedure
both ovaries will be measured in three dimensions with ultrasonography
次要结局
未报告次要终点
研究者
Berna Aslan Cetin
Md, ObGYN
Kanuni Sultan Suleyman Training and Research Hospital