The Influences of Single Chamber vs. Multi-chamber Blood Flow Restriction Cuffs on Post-exercise Arterial Stiffness, Perceptual Responses and Performance
试验速览
- 阶段
- 不适用
- 状态
- 进行中(未招募)
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Muscle Morphology
研究概览
简要总结
The purpose of this study is to investigate the use of single (SC) and multi-chamber (MC) blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, and participant perception.
详细描述
Thirty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), SC BFR, and MC BFR) in a randomized order separated by one week. A familiarization session will also occur one week before starting the treatment period. Each subject will undergo a series of tests including anthropometry, ultrasonography of the carotid artery, applanation tonometry, ultrasonography of the vastus lateralis, blood pressure acquisition, body composition, and maximal strength assessments (1RM). The exercise trial will consist of sets of dumbbell wall squats performed to failure with a 2-seconds concentric and 2-seconds eccentric cadence, at 20% of their 1RM using 60% of the supine limb occlusion pressure (LOP) with 1-minute rest intervals. Assessments will be performed immediately before and after the exercise bout during each treatment session. Two-way ANOVAs will be used to examine the main effects of treatment and treatment-order interaction on pulse wave velocity, muscle cross-sectional area, and perceptual response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Unable to blind due to differences in cuff size and appearance.
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Physically active (> 1,000 MET/min/wk) for at least six months.
- •Weight stable for previous 6 months (+/-2.5 kg)
- •Female subjects only- reported regular menstrual cycles for the last 2 years
排除标准
- •BP>140/90 mmHg
- •BMI>40 kg/m2
- •Familial hypercholesterolemia
- •Past or current history of CHD, stroke or major CVD events. Respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject.
- •Women must not be pregnant, plan to become pregnant during the study, or be nursing
- •Active renal or liver disease
- •All medications and supplements that influence dependent variables*
- •Recent surgery < 2 months
- •Alcohol abuse
- •Sleep apnea
- •Claustrophobia
结局指标
主要结局
Muscle Morphology
时间窗: Prior to and immediately after the exercise intervention
A measurement of vastus lateralis cross sectional area
Arterial Stiffness
时间窗: Prior to and 10-minutes after the exercise intervention
A measurement of vascular health.
次要结局
未报告次要终点
研究者
Timothy Werner
Associate Professor
Salisbury University
