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临床试验/NCT06276673
NCT06276673进行中(未招募)不适用

The Influences of Single Chamber vs. Multi-chamber Blood Flow Restriction Cuffs on Post-exercise Arterial Stiffness, Perceptual Responses and Performance

Salisbury University2 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2024年2月13日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
35
试验地点
2
主要终点
Muscle Morphology

研究概览

简要总结

The purpose of this study is to investigate the use of single (SC) and multi-chamber (MC) blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, and participant perception.

详细描述

Thirty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), SC BFR, and MC BFR) in a randomized order separated by one week. A familiarization session will also occur one week before starting the treatment period. Each subject will undergo a series of tests including anthropometry, ultrasonography of the carotid artery, applanation tonometry, ultrasonography of the vastus lateralis, blood pressure acquisition, body composition, and maximal strength assessments (1RM). The exercise trial will consist of sets of dumbbell wall squats performed to failure with a 2-seconds concentric and 2-seconds eccentric cadence, at 20% of their 1RM using 60% of the supine limb occlusion pressure (LOP) with 1-minute rest intervals. Assessments will be performed immediately before and after the exercise bout during each treatment session. Two-way ANOVAs will be used to examine the main effects of treatment and treatment-order interaction on pulse wave velocity, muscle cross-sectional area, and perceptual response.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

盲法说明

Unable to blind due to differences in cuff size and appearance.

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Physically active (> 1,000 MET/min/wk) for at least six months.
  • Weight stable for previous 6 months (+/-2.5 kg)
  • Female subjects only- reported regular menstrual cycles for the last 2 years

排除标准

  • BP>140/90 mmHg
  • BMI>40 kg/m2
  • Familial hypercholesterolemia
  • Past or current history of CHD, stroke or major CVD events. Respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject.
  • Women must not be pregnant, plan to become pregnant during the study, or be nursing
  • Active renal or liver disease
  • All medications and supplements that influence dependent variables*
  • Recent surgery < 2 months
  • Alcohol abuse
  • Sleep apnea
  • Claustrophobia

结局指标

主要结局

Muscle Morphology

时间窗: Prior to and immediately after the exercise intervention

A measurement of vastus lateralis cross sectional area

Arterial Stiffness

时间窗: Prior to and 10-minutes after the exercise intervention

A measurement of vascular health.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Timothy Werner

Associate Professor

Salisbury University

研究点 (2)

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