Optimization of Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients With an Implanted Port Catheter
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Vancomycin trough levels via port catheter and peripheral vein
Study Overview
Brief Summary
The goal of this study is to verify whether extensive flushing of the port catheter in patients with catheter related blood stream infection will lead to correct vancomycin trough levels, taken via the port catheter and compared with simultaneously taken peripheral samples.
Detailed Description
In this study, extensive flushing of the port catheter prior to blood sampling to determine vancomycin trough levels, will be compared with normal flushing. To ascertain correctness of the trough levels taken via the central catheter, sampling will occur through a peripheral catheter simultaneously.
Flushing will be done with sodium chloride 0.9 % solution.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- — to 18 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Pediatric patients with a port catheter
- •Treated with systemic vancomycin and/or vancomycin "lock"
Exclusion Criteria
- •Age > 18 years
- •Active downgrading of care
Arms & Interventions
Patients with port catheter: flushing
In patients with a catheter-related blood stream infection (CRBSI) and a port catheter, being treated with vancomycin intravenously, we will flush the catheter with 30 ml of sodium chloride 0.9 % prior to blood sampling to determine vancomycin concentrations, in order to decrease residuel vancomycin in the port.
Intervention: Extensive flushing of the port catheter (Procedure)
Outcomes
Primary Outcomes
Vancomycin trough levels via port catheter and peripheral vein
Time Frame: At steady state i.e. approximately 36 hours after initation of the treatment or a change in dose
Vancomycin trough levels will be determined, both on peripheral blood and blood taken via the port catheter and will be compared.
Secondary Outcomes
No secondary outcomes reported
Investigators
Isabelle Spriet
PharmD, PhD
Universitaire Ziekenhuizen KU Leuven