Optimization of Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients With an Implanted Port Catheter
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Vancomycin trough levels via port catheter and peripheral vein
研究概览
简要总结
The goal of this study is to verify whether extensive flushing of the port catheter in patients with catheter related blood stream infection will lead to correct vancomycin trough levels, taken via the port catheter and compared with simultaneously taken peripheral samples.
详细描述
In this study, extensive flushing of the port catheter prior to blood sampling to determine vancomycin trough levels, will be compared with normal flushing. To ascertain correctness of the trough levels taken via the central catheter, sampling will occur through a peripheral catheter simultaneously.
Flushing will be done with sodium chloride 0.9 % solution.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pediatric patients with a port catheter
- •Treated with systemic vancomycin and/or vancomycin "lock"
排除标准
- •Age > 18 years
- •Active downgrading of care
结局指标
主要结局
Vancomycin trough levels via port catheter and peripheral vein
时间窗: At steady state i.e. approximately 36 hours after initation of the treatment or a change in dose
Vancomycin trough levels will be determined, both on peripheral blood and blood taken via the port catheter and will be compared.
次要结局
未报告次要终点
研究者
Isabelle Spriet
PharmD, PhD
Universitaire Ziekenhuizen KU Leuven