To compare the level of a biochemical substance in the fluid around a screw after its placement and applying a force through a wire on it - An initial study
Phase 2
- Registration Number
- CTRI/2019/02/017791
- Lead Sponsor
- Dr HITESH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Age 15 to 25 years irrespective of the gender.
2. Subjects requiring bilateral first premolar extraction.
3. Positive informed consent.
4. No history of any systemic disease, hormonal imbalance, and anti-inflammatory drug intake in the near past.
5. Healthy periodontal tissue with generalized probing depth less than or equal to 3 mm.
Exclusion Criteria
1. Patient with systemic conditions affecting bone metabolism and implant placement.
2. History of inflammatory drug administration in 6 months preceding the study.
3. Non-compliant patient with inability to maintain oral hygiene.
4. Not willing informed consent.
5. Patient with the habit of smoking or use of tobacco.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To estimate and compare the levels of IL-1β in the PMICF post immediate and delayed (after 3- <br/ ><br>week cooling period) loading in cases requiring canine retraction by indirect loading method.Timepoint: In 7 visits at 0th, 1st, 21st, 22nd, 43rd, 72nd and 120th day
- Secondary Outcome Measures
Name Time Method 1.To quantify the release of IL-1β in the PMICF . <br/ ><br>2.To compare the levels of the biomarker. <br/ ><br>3.To compare the results of biomarker quantification of immediate and delayed loading methods.Timepoint: In 7 visits at 0th, 1st, 21st, 22nd, 43rd, 72nd and 120th day