Positron Emission Tomography for Staging, and Treatment Assessment of Response in Lymphomas (the Pet-star Lymphoma Study)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hodgkin's Lymphoma
- Sponsor
- University Health Network, Toronto
- Enrollment
- 103
- Locations
- 1
- Primary Endpoint
- To determine:the frequency in which the FDG-PET scan result will change the clinical management of the patient, and to record the intervention instituted within 3 months of the PET scan 2)early relapse rates for PET positive, and PET negative patients.
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
This study examines the role of a diagnostic test called Positron Emission Tomography (PET) scanning in patients with malignant lymphoma. The primary goal of this study is to find out how well PET scanning can detect malignant (cancerous) lymphoma, and how often this extra information will result in a change of stage of disease, or will result in a change in treatment management plans of patients with lymphoma.
Detailed Description
It is currently unknown whether modifying treatment based on FDG-PET results is appropriate. However, clinicians are increasingly using the FDG-PET result, where obtained, in deciding management. Consequently, it would be premature to mandate PET-based treatment modifications in this protocol. Patients will be treated with existing protocols at the discretion of their treating oncologists, based on available information. Oncologists will be surveyed as to whether FDG-PET scan results could have (or affect patient management, and the intervention will be recorded).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients \> 18 years of age.
- •Confirmed diagnosis of HL or NHL (any histology).
- •Any Ann Arbor stage.
- •Pre-treatment staging including CT of head and neck, chest, abdomen and pelvis, where there is a minimum one equivocal finding on the scan, affecting the assignment of stage or IPI factor (i.e. stage III/IV vs. stage I/II, or a question of extranodal involvement by disease).
- •Group B: Response Assessment
- •Inclusion Criteria:
- •Patients \> 18 years of age.
- •Confirmed diagnosis of HL or NHL (any histology).
- •Any Ann Arbor stage.
- •Pre-treatment staging including CT neck, chest, abdomen and pelvis. If alternate assessment of the neck done by clinical palpitation, ultrasound, or MRI is negative, CT neck is not mandatory.
Exclusion Criteria
- •Response Assessment
- •None Curative treatment Intent
- •After initial therapy the response status is: complete response, stable disease, or progressive disease
Outcomes
Primary Outcomes
To determine:the frequency in which the FDG-PET scan result will change the clinical management of the patient, and to record the intervention instituted within 3 months of the PET scan 2)early relapse rates for PET positive, and PET negative patients.
Time Frame: 24 months
Secondary Outcomes
- To:1) describe & quantify potential changes in clinical practice caused by the adoption of FDG-PET scanning 2)correlate FDG-PET scan findings with disease characteristics, traditional standard response criteria, biopsy results, & early clinical outcome.(24 months)