Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Not Applicable

Completed

• Conditions: Dietary Supplementation
• Interventions: Dietary Supplement: Grape seed extract

• Registration Number: NCT05945771
• Lead Sponsor: California Baptist University

Brief Summary

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-01
• Primary Completion: 2022-08-31
• Study Completion: 2022-08-31
• Status Verified: 2023-07
• Study First Submitted: 2023-07-03
• Study First Submitted QC: 2023-07-12
• Last Update Submitted: 2023-07-12
• Study First Posted: 2023-07-14
• Last Update Posted: 2023-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)

Exclusion Criteria

• cardiovascular and/or pulmonary disease,
• musculoskeletal disorders
• medications that prevent the safe completion of the exercise protocol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Randomized double blind grape seed extract design	Grape seed extract	Grape seed extract
Control	Grape seed extract	Placebo (starch)

Primary Outcome Measures

Name	Time	Method
Diastolic blood pressure (mmHg) by sphygmomanometer	24 hours	Measured from the brachial artery
Heart rate (bpm)	24 hours	measured using Physio Flow (non-invasive device)
Total peripheral resistance (mmHg/l/min)	24 hours	calculated: MAP (mmHg) / CO (l/min)
Mean arterial pressure (mmHg)	24 hours	calculated (MAP = (SBP-DBP)/3 + DBP
Stroke volume (ml)	24 hours	measured using Physio Flow (non-invasive device)
Systolic blood pressure (mmHg) by sphygmomanometer	24 hours	Measured from the brachial artery
Cardiac output (l/min)	24 hours	calculated: HR (bpm) x SV (ml)

Trial Locations

Locations (1)

California Baptist University; 🇺🇸 Riverside, California, United States