Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 12
- Locations
- 2
- Primary Endpoint
- Stroke volume (ml)
Study Overview
Brief Summary
The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)
Exclusion Criteria
- •cardiovascular and/or pulmonary disease,
- •musculoskeletal disorders
- •medications that prevent the safe completion of the exercise protocol
Outcomes
Primary Outcomes
Stroke volume (ml)
Time Frame: 24 hours
measured using Physio Flow (non-invasive device)
Diastolic blood pressure (mmHg) by sphygmomanometer
Time Frame: 24 hours
Measured from the brachial artery
Heart rate (bpm)
Time Frame: 24 hours
measured using Physio Flow (non-invasive device)
Total peripheral resistance (mmHg/l/min)
Time Frame: 24 hours
calculated: MAP (mmHg) / CO (l/min)
Mean arterial pressure (mmHg)
Time Frame: 24 hours
calculated (MAP = (SBP-DBP)/3 + DBP
Systolic blood pressure (mmHg) by sphygmomanometer
Time Frame: 24 hours
Measured from the brachial artery
Cardiac output (l/min)
Time Frame: 24 hours
calculated: HR (bpm) x SV (ml)
Secondary Outcomes
No secondary outcomes reported