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Clinical Trials/NCT05945771
NCT05945771CompletedNot Applicable

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy

California Baptist University2 sites in 1 country12 target enrollmentStarted: May 1, 2022Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
12
Locations
2
Primary Endpoint
Stroke volume (ml)

Study Overview

Brief Summary

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Prevention
Masking
Double (Participant, Investigator)

Eligibility Criteria

Ages
18 Years to 30 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)

Exclusion Criteria

  • cardiovascular and/or pulmonary disease,
  • musculoskeletal disorders
  • medications that prevent the safe completion of the exercise protocol

Outcomes

Primary Outcomes

Stroke volume (ml)

Time Frame: 24 hours

measured using Physio Flow (non-invasive device)

Diastolic blood pressure (mmHg) by sphygmomanometer

Time Frame: 24 hours

Measured from the brachial artery

Heart rate (bpm)

Time Frame: 24 hours

measured using Physio Flow (non-invasive device)

Total peripheral resistance (mmHg/l/min)

Time Frame: 24 hours

calculated: MAP (mmHg) / CO (l/min)

Mean arterial pressure (mmHg)

Time Frame: 24 hours

calculated (MAP = (SBP-DBP)/3 + DBP

Systolic blood pressure (mmHg) by sphygmomanometer

Time Frame: 24 hours

Measured from the brachial artery

Cardiac output (l/min)

Time Frame: 24 hours

calculated: HR (bpm) x SV (ml)

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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