-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.

Not Applicable

Completed

• Conditions: Type 2 Diabetes
• Interventions: Dietary Supplement: Oleic acid; Dietary Supplement: GPR 119 agonist, 2-oleyl glycerol; Dietary Supplement: Vehicle

• Registration Number: NCT01043445
• Lead Sponsor: Glostrup University Hospital, Copenhagen

Brief Summary

The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.

Detailed Description

We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2009-12-02
• Study First Submitted QC: 2010-01-05
• Study First Posted: 2010-01-06
• Primary Completion: 2010-03
• Study Completion: 2010-04
• Status Verified: 2014-10
• Last Update Submitted: 2014-10-08
• Last Update Posted: 2014-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• Healthy caucasians v- Normal OGTT (75 g of glucose) according to WHO's criteria
• Normal hemoglobin
• Informed consent

Exclusion Criteria

• Liver disease (ALAT> 2x normal level)
• Nephropathy (s-creatinin >130 microM or albuminuria)
• Relatives with type 2 diabetes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
GPR119 agonist, 2-oleoyl glycerol	Vehicle	2-oleoyl glycerol; 2g. and vehicle
Oleic acid	Oleic acid	oleic acid; 3.2g and vehicle
GPR119 agonist, 2-oleoyl glycerol	GPR 119 agonist, 2-oleyl glycerol	2-oleoyl glycerol; 2g. and vehicle
Oleic acid	Vehicle	oleic acid; 3.2g and vehicle
Vehicle	Vehicle	5 ml. of glycerol and 5 ml 96% ethanol

Primary Outcome Measures

Name	Time	Method
The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects	1 year

Secondary Outcome Measures

Name	Time	Method
Glucose homeostasis, gall bladder contraction in response of the different meals administered to the subjects	1 year

Trial Locations

Locations (1)

Department of Clinical Physiology, Glostrup Hospital; 🇩🇰 Glostrup, Denmark