NCT01043445已完成不适用
G Protein-coupled Receptor in the Intestine (GPR 119) Stimulated GLP-1 Secretion
Glostrup University Hospital, Copenhagen2 个研究点 分布在 1 个国家目标入组 8 人开始时间: 2009年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects
研究概览
简要总结
The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.
详细描述
We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy caucasians v- Normal OGTT (75 g of glucose) according to WHO's criteria
- •Normal hemoglobin
- •Informed consent
排除标准
- •Liver disease (ALAT> 2x normal level)
- •Nephropathy (s-creatinin >130 microM or albuminuria)
- •Relatives with type 2 diabetes
结局指标
主要结局
The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects
时间窗: 1 year
次要结局
- Glucose homeostasis, gall bladder contraction in response of the different meals administered to the subjects(1 year)
研究者
Katrine Bagge Hansen
MD, Ph.d
Glostrup University Hospital, Copenhagen
研究点 (2)
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