Phenylephrine versus EPhedrine on cerebral Perfusion during Carotid EndarteRectomy

Completed

• Conditions: 10011954; intraoperative hypotension; low blood pressure during surgery; 10003184

• Registration Number: NL-OMON38169
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-11-01
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

To be included in the current study all patients must meet the following criteria:
1. Undergoing CEA because of a symptomatic high degree stenosis of the ICA in the University Medical Centre Utrecht
2. Having an appropriate temporal bone window for reliable perioperative TCD monitoring
3. Have given written informed consent.
4. A decrease in MAP >20%

Exclusion Criteria

Exclusion criteria
Patients will be excluded if they meet one of the following criteria:
1. Not having a temporal bone window appropriate for TCD measurement
2. Not willing to give informed consent.
3. No decrease in MAP >20%
4. A heart rate less than 50 beats per minute at the time of administration.
5. Hypersensitivity to either ephedrine of phenylephrine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in cerebral oxygenation (rSO2) measured using Near Infrared<br /><br>Spectroscopy (NIRS).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Change in velocity measured in the a. cerebri media (Vmca) measured using<br /><br>transcranial Doppler (TCD).<br /><br>The cerebral autoregulation will be quantified as being adequate or<br /><br>non-adequate.</p><br>