Effect of preoperative infusion of dexmedetomidine on intraoperative anaesthetic drug consumption under general anaesthesia

Phase 4

Completed

• Conditions: Patient with American Society of Anaesthesiologists Physical status 1 and 2 posted for elective surgery under general anaesthesia

• Registration Number: CTRI/2020/06/026088
• Lead Sponsor: M S RAMAIAH MEDICAL COLLEGE

Brief Summary

General anaesthesia with inhalational agents associated with adjuvant intravenous agents provide better sedation, hypnosis and analgesia. Drugs with such effects already established in literature include benzodiazepines and opioids. New intravenous agents like alpha2 adrenergic agonist produce sedation ,anxiolysis and analgesia and has good haemodynamic profile.

Hence, it is hypothesized that preinduction loading dose of dexmedetomidine  1 microgram/kg would reduce inhalational anaesthesia agent isoflurane consumption and thus cost effective and also provide better haemodynamic stability and recovery profile.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-10
• Study Completion: 2015-09-28
• Last Update Posted: 2020-01-19

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age between 20 and 60 years.
• American Society of Anaesthesiologists Grade 1 and 2.
• Patients undergoing surgeries under general anaesthesia.

Exclusion Criteria

• Patients allergic to study drug.
• Patients undergoing laparoscopic surgeries.
• Body Mass Index > 35 kg/m2.
• Patients on beta blockers,sedatives or stimulant drugs. -Patients with history of psychiatric illness,alcohol abusers,altered mentation or epilepsy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the effect of preanaesthetic administration of dexmedetomidine on isoflurane consumption.	At the end of the surgery

Secondary Outcome Measures

Name	Time	Method
To assess effect of dexmedetomidine on intraoperative haemodynamic stability and recovery profile.	Baseline,every 5 minutes after infusion of study drug/placebo till end of anaesthesia heart rate,blood pressure,oxygen saturation,bispectral index values were noted. Postoperative recovery profiles were assessed using modified aldrete score at immediate postop,30 and 60 minutes.

Trial Locations

Locations (1)

M S RAMAIAH MEDICAL HOSPITAL; 🇮🇳 Bangalore, KARNATAKA, India

M S RAMAIAH MEDICAL HOSPITAL

🇮🇳Bangalore, KARNATAKA, India

RESHMA B M

Principal investigator

8892019120

lucky3276@gmail.com