Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery

Completed

• Conditions: Postoperative Cognitive Dysfunction; Postoperative Delirium; Astrogliosis
• Interventions: Diagnostic Test: Glial fibrillary acidic protein

• Registration Number: NCT03683537
• Lead Sponsor: Moscow Clinical Scientific Center

Brief Summary

Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day. Neuropsychological testing before surgery and on 3 or 4 day after surgery. Investigation of relationship between changes of GFAP and scores of neuropsychological tests.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-15
• Study First Submitted: 2018-09-20
• Study First Submitted QC: 2018-09-21
• Study First Posted: 2018-09-25
• Primary Completion: 2021-11-15
• Study Completion: 2021-12-15
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-06
• Last Update Posted: 2025-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with different diseases, who require prolonged laparoscopy or open surgery
• Age more than 60
• ASA I-III
• Informed consent to participate in the study

Exclusion Criteria

• ASA IV-V
• Severe neurodegenerative or psychological diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Delayed Neurocognitive decline	Glial fibrillary acidic protein	Patients in whom there is Delayed Neurocognitive Recovery (DNR) after surgery, based on neuropsychological tests or clinically. DNR is defined as follow: 1)decrease of scores of neuropsychological test scores for more than 1 standard deviation (SD) of these tests; 2)clinically - inability of patient to perform test after surgery because of neurocognitive impairment.
Normal postop neurocognitive function	Glial fibrillary acidic protein	Patients in whom there is no clinical signs of DNR, defined as in previous group.

Primary Outcome Measures

Name	Time	Method
Changes in serum GFAP	1 year	GFAP(3) - GFAP (1); GFAP (2) - GFAP (1)

Trial Locations

Locations (1)

Moscow Clinical Scientific Center; 🇷🇺 Moscow, Russian Federation