Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
Trial Snapshot
- Phase
- Phase 1
- Status
- Recruiting
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Blood flow
Study Overview
Brief Summary
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy women,
- •Assigned female at birth,
- •18-70 years of age,
- •Body mass index <18 or ≥30 kg/m2,
Exclusion Criteria
- •Assigned male at birth,
- •Pregnancy,
- •Breastfeeding,
- •History of hormone replacement therapy, chemical menopause, or oophor-ectomy
- •Polycystic ovarian syndrome or Primary ovarian insufficiency,
- •Current smoking/Nicotine use,
- •Blood pressure ≥140/90 mmHg,
- •Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy,
- •Nerve/neurologic disease,
- •Cardiovascular, hepatic, renal, respiratory disease,
- •Hypersensitivity to nitroglycerin,
- •Diabetes,
- •Communication barriers,
Arms & Interventions
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
Intervention: Gemtesa (Drug)
Flow Mediated Dilation
Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm.
Intervention: Placebo (Drug)
Flow Mediated Dilation
Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm.
Intervention: Gemtesa (Drug)
Cold pressor test
Participants will be exposed to the cold pressor test (ice water on the foot).
Intervention: Placebo (Drug)
Outcomes
Primary Outcomes
Blood flow
Time Frame: Change from baseline to minute 2.
Blood flow measured with Doppler ultrasound.
Secondary Outcomes
No secondary outcomes reported
Investigators
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia