Intraoperative Hypotension and Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery
- Conditions
- Coronary Artery Bypass, Off-PumpIntraoperative HypotensionAcute Kidney Injury
- Registration Number
- NCT03889730
- Lead Sponsor
- Peking University First Hospital
- Brief Summary
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Hypotension is an important risk factor for the development of AKI after noncardiac surgery. However, the association between intraoperative hypotension and AKI after cardiac surgery has not been fully investigated. The purpose of this study is to analyze the association between intraoperative hypotension and acute kidney injury after off-pump coronary artery bypass surgery.
- Detailed Description
Acute renal injury (AKI) is a common complication after cardiac surgery. Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with increased in-hospital mortality, prolonged length of stay in the Intensive Care Unit and hospital, and higher costs of care. Intraoperative hypotension is an important risk factor for the development of AKI after noncardiac surgery. In a retrospective analysis, a mean arterial pressure of less than 55 mmHg predicted the occurrence of adverse cardiac- and renal-related outcomes after noncardiac surgery. Other studies also revealed that intraoperative hypotension is associated with increased incidence of AKI and 1-year mortality after noncardiac surgery. In patients undergoing cardiac surgery, 30-day mortality is proportionate to the extent of systolic blood pressure excursions outside the range of 75 to 135 mm Hg intraoperatively. However, the correlation between intraoperative hypotension and the development of AKI after cardiac surgery has not been fully investigated. The purpose of this study is to analyze the association between intraoperative hypotension and the risk of acute kidney injury after off-pump coronary artery bypass surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 821
- Age ≥ 50 years;
- Underwent off-pump CABG surgery.
- End-stage renal disease requiring renal-replacement therapy;
- Emergency surgery;
- Kidney transplantation within 3 months;
- Missing data.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of acute kidney injury (AKI) within 7 days after surgery Up to 7 days after surgery Development of AKI within 7 days after surgery is diagnosed according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria
- Secondary Outcome Measures
Name Time Method Duration of mechanical ventilation after surgery Up to 30 days after surgery Duration of mechanical ventilation after surgery
Length of stay in intensive care unit (ICU) after surgery Up to 30 days after surgery Length of stay in intensive care unit (ICU) after surgery
Incidence of major adverse cardiovascular events (MACEs) within 30 days after surgery Up to 30 days after surgery MACEs within 30 days after surgery include cardiovascular death, non-fatal cardiac arrest, acute myocardial infarction, revascularization, and ischemic stroke.
Classification of AKI within 7 days after surgery Up to 7 days after surgery Development of AKI within 7 days after surgery is diagnosed according to the KDIGO criteria
Incidence of non-MACE complications within 30 days after surgery Up to 30 days after surgery Non-MACE complications within 30 days after surgery indicate new-onset medical conditions other than MACEs that produce harmful effects on patients' recovery and required therapeutic intervention.
All-cause mortality in hospital Up to 30 days after surgery All-cause mortality in hospital
Length of stay in hospital after surgery Up to 30 days after surgery Length of stay in hospital after surgery
Trial Locations
- Locations (1)
Peking University First Hospital
🇨🇳Beijing, Beijing, China