An Assessment of Vasoactive Medication Dose in Mechanically Ventilated Patients Undergoing Daily Sedation Awakening Trial (SAT)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- change in vasoactive drug dose
研究概览
简要总结
To assess the impact of daily awakening from sedation on the amount of vasoactive medication required in the ICU. The hypothesis of this proposal is that the amount of vasoactive drug required to maintain an adequate mean arterial blood pressure will be reduced during a daily awakening from sedation.
详细描述
This observational study will compare mean arterial pressure and vasoactive drug dose recorded at two time points:
- prior to awakening from sedation
- during the awakening from sedation trial The vasoactive infusion will be titrated to a mean arterial pressure as determined by the medical team prior to study enrollment. Each enrolled patient will have measurements taken only on the first day of enrollment. Enrolled subjects will also have a delirium assessment using the CAM-ICU tool before the awakening from sedation trial and during the awakening from sedation trial.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •requiring Mechanical ventilation through an endotracheal tube with infusion of sedative or analgesic agent for comfort
- •requiring vasoactive drug via central venous catheter for the treatment of shock
排除标准
- •patients receiving Dexmedetomidine as sedative
研究组 & 干预措施
Mechanical Ventilation (MV) with vasoactive infusions
adult ICU patients who are mechanically ventilated with sedative infusion and/or analgesic infusion and also requiring vasoactive drug infusions for the treatment of shock. Patients will be excluded if receiving dexmedetomidine as sedative.
干预措施: sedation awakening trial (Other)
结局指标
主要结局
change in vasoactive drug dose
时间窗: baseline thru study completion on average < 4 hrs
mcg/kg/min baseline dose and nadir dose
次要结局
- change in mean arterial blood pressure(baseline thru study completion on average <4 hrs)
- change in prevalence of ICU delirium(baseline thru study completion on average <4hrs)