NCT04676035已完成1 期
A Single-center, Open-label, Fixed-sequence Phase I Drug-drug Interaction Clinical Study to Investigate the Pharmacokinetics of SHR3680 With Midazolam （CYP3A4 Substrates), S-Warfarin (CYP2C9 Substrates) and Omeprazole (CYP2C19 Substrates) in Prostate Cancer Patients
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Pharmacokinetics parameters of Midazolam, S-Warfarin and Omeprazole
研究概览
简要总结
The DDI study had been designed to investigate the effect of SHR3680 on the pharmacokinetics of Midazolam, S-Warfarin and Omeprazole
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •18 ≤ age ≤75, male;
- •ECOG score of physical condition is 0 ~ 1;
- •The expected survival time is at least 3 months;
- •Prostatic adenocarcinoma confirmed by histological or cytological examination, with no indication of neuroendocrine or small-cell characteristics;
- •The functional level of organs must meet the following requirements (no blood transfusion or hematopoietic growth factor treatment was received within 2 weeks before routine blood screening) :
- •ANC ≧ 1.5 x 109 / L;
- •PLT ≧ 80 x 109 / L;
- •Hb ≧ 90 g/L;
- •TBIL ≦1.5 x ULN;
- •ALT and AST≦2.5×ULN;
- •BUN and Cr ≦1.5 x ULN;
- •GFR ≧ 60 ml/min / 1.73 m
- •According to the researcher's judgment, it can comply with the experimental scheme;
- •Volunteer to participate in this clinical trial, understand the study procedures and have signed informed consent.
排除标准
- •Any previous anti-tumor therapy (including radiotherapy, chemotherapy, surgery, molecular targeted therapy, immunotherapy, etc.), except ADT therapy, shall be completed until the washout period of the first drug administration in this study is <4 weeks;
- •Plan to receive any other anti-tumor therapy during the study;
- •As subjects, to participate in other drug clinical trials, the last trial drug administration is less than 4 weeks from the first administration of the drug in this study;
- •The presence of intracerebral tumor lesions according to imaging diagnosis;
- •Have a history of epilepsy, or have diseases that can induce epileptic seizures within 12 months before the first administration of the drug in this study (including a history of transient ischemic attack, cerebral stroke (except cerebral ischemia lesions found by simple imaging examination), and need to be hospitalized with cerebral trauma and consciousness disorder);
- •Active heart disease, including severe/unstable angina, myocardial infarction, symptomatic congestive heart failure, and drug-requiring ventricular arrhythmias, within 6 months prior to the first administration of the drug in this study;
- •Inability to swallow, chronic diarrhea and ileus, history of gastrointestinal surgery, or other factors affecting drug use and absorption as determined by the investigator;
- •Patients with active HBV or HCV infection (HBV copy count ≥ 104 copies /mL, HCV copy count ≥ 103 copies /mL) and active syphilis;
- •A history of immunodeficiency (including HIV positive, other acquired or congenital immunodeficiency diseases) or a history of organ transplantation;
- •Patients who were unwilling to use effective contraceptive methods during the whole study treatment period and within 3 months after the last administration;
- •Allergic constitution, including a history of severe drug allergy or drug allergy;
- •Screening for excessive smoking in the first 6 months (≥5 cigarettes/day) or smoking within 48 hours before the first dose, or not interrupting smokers during the main study trial, and screening for drug use in the first 3 months with a history of drug abuse or positive drug abuse screening;
- •has a history of alcoholism or within 6 months prior to screening often drinkers, namely the essence of drinking more than 14 units of alcohol a week (1 = 360 mL of alcohol content of 5% beer or 45 mL of 40% alcohol liquor or 150 mL wine alcohol content of 12%) or within 48 h before taking the medicine for the first time drinking, or D - 1 in the alcohol breath test positive, or the body can't stop alcohol intake during the study period;
- •Use of any vitamin product, health product or herb 14 days prior to the first administration;
- •Ingestion of grapefruit or fruit juice products such as grapefruit, foods or beverages containing caffeine, xanthine or alcohol within 48 hours before taking the study drug;Strenuous exercise, or other factors affecting drug absorption, distribution, metabolism, and excretion;
- •Within 2 weeks before the first drug uptake, uptake CYP3A4, CYP2C9 and CYP2C19 inhibitors were used, or drugs affecting gastric acid secretion. (Annex I);
- •abnormal coagulation function at screening stage (INR >1.5 or prothrombin time (PT) > ULN+4 seconds or APTT> 1.5uln), bleeding tendency or thrombolytic therapy;
- •Patients treated with anticoagulants or vitamin K1 antagonists such as warfarin, heparin, or similar drugs;
- •Note: Under the condition that the international standard ratio of prothrombin time (INR) ≤1.5, low-dose heparin (66,000-12,000U daily for adults) or low-dose aspirin (100mg daily) is allowed for preventive purposes;
- •Midazolam contraindications (benzodiazepine allergy, myasthenia gravis, schizophrenia, severe depression);
- •Contraindications to Warfarin (liver and kidney function impairment, severe hypertension, coagulation dysfunction with bleeding tendency, active ulcer, trauma, threatened abortion, recent surgery);
- •Concomitant diseases (such as poorly controlled hypertension, severe diabetes, thyroid disease, psychosis, etc.) or any other conditions that, in the investigator's judgment, would seriously endanger the patient's safety or affect the patient's completion of the study.
研究组 & 干预措施
SHR3680+ Midazolam, Warfarin, Omeprazole, VitaminK1
Experimental
administrate Midazolam, Warfarin, Omeprazole, VitaminK1 on Day1 and Day22, SHR3680 on day 6-27.
干预措施: Midazolam, Warfarin, Omeprazole, VitaminK1 and SHR3680 (Drug)
结局指标
主要结局
Pharmacokinetics parameters of Midazolam, S-Warfarin and Omeprazole
时间窗: Day1 and Day22
Area under the plasma concentration versus time curve (AUC)
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
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