A randomised controlled trial to compare the anaesthetic potency and hemodynamic effects of levobupivacaine+buprenorphine and bupivacaine+buprenorphine
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- onset of sensory blockade with levobupivacaine faster than bupivacaine
Study Overview
Brief Summary
Levobupivacaine the pure S(-) enantiomer of racemic bupivacaine, is a new long acting local anaesthetic that has recently been introduced in the clinical routine. Because of its significantly decreased cardiovascular and central nervous system toxicity, levobupivacaine seems to be an attractive alternative to bupivacaine. It has become a popular practice to add opioids to local anaesthetic solutions to enhance and prolong intraoperative and postoperative analgesia. However lack of comparative studies and adequate information on the anaesthetic potency of levobupivacaine with an opioid prompted us to investigate the anaesthetic potency and hemodynamic effects of bupivacaine with buprenorphine compared with levobupivacaine with buprenorphine in patients undergoing upper limb surgeries in a prospective randomized double blinded study
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant, Investigator and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients aged between 18-60 yrs with ASA physical status I–II who are scheduled for elective upper limb surgeries under brachial plexus block.
Exclusion Criteria
- •1.Known hypersensitivity to amide local anesthetics
- •Morbid obesity (150% the ideal weight or >130 kg).
Outcomes
Primary Outcomes
onset of sensory blockade with levobupivacaine faster than bupivacaine
Time Frame: checked at baseline and then every 5 minutes for 30 minutes
Secondary Outcomes
- Better hemodynamic stability in levobupivacaine group(Blood pressure and pulse rate checked at base line and every 5 minutes for 2 hours)