A randomised controlled trial to compare the anaesthetic potency and hemodynamic effects of levobupivacaine+buprenorphine and bupivacaine+buprenorphine
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- onset of sensory blockade with levobupivacaine faster than bupivacaine
研究概览
简要总结
Levobupivacaine the pure S(-) enantiomer of racemic bupivacaine, is a new long acting local anaesthetic that has recently been introduced in the clinical routine. Because of its significantly decreased cardiovascular and central nervous system toxicity, levobupivacaine seems to be an attractive alternative to bupivacaine. It has become a popular practice to add opioids to local anaesthetic solutions to enhance and prolong intraoperative and postoperative analgesia. However lack of comparative studies and adequate information on the anaesthetic potency of levobupivacaine with an opioid prompted us to investigate the anaesthetic potency and hemodynamic effects of bupivacaine with buprenorphine compared with levobupivacaine with buprenorphine in patients undergoing upper limb surgeries in a prospective randomized double blinded study
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged between 18-60 yrs with ASA physical status I–II who are scheduled for elective upper limb surgeries under brachial plexus block.
排除标准
- •1.Known hypersensitivity to amide local anesthetics
- •Morbid obesity (150% the ideal weight or >130 kg).
结局指标
主要结局
onset of sensory blockade with levobupivacaine faster than bupivacaine
时间窗: checked at baseline and then every 5 minutes for 30 minutes
次要结局
- Better hemodynamic stability in levobupivacaine group(Blood pressure and pulse rate checked at base line and every 5 minutes for 2 hours)