ISRCTN75393495已完成不适用
The Effect of Long term Low dose Erythromycin on cough frequency in chronic unexplained cough: a randomised double-blind placebo controlled parallel group trial
niversity Hospitals of Leicester NHS Trust (UK)0 个研究点目标入组 40 人开始时间: 2007年8月6日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Cough lasting greater than eight weeks
- •2. Normal Spirometry
- •3. A Provocative Concentration of methacholine required to cause a 20% fall (PC20) in Forced Expiratory Volume in one second (FEV1) of greater than 8 mg/ml
- •4. A normal sputum eosinophil count (less than 3%)
- •5. No response to a three-month trial of treatment with a high dose Proton-Pump Inhibitor (PPI)
- •6. No response to a trial of a nasal steroid
- •7. A normal thoracic Computed Tomography (CT)
排除标准
- •1. Current smokers or past smokers with a greater than 10 pack year history will be excluded
- •2. Those with a history of intolerance macrolide antibiotics
- •3. Pregnant or breastfeeding women
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