Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression
- Conditions
- Migraine
- Interventions
- Genetic: Migraine CNV
- Registration Number
- NCT04912752
- Lead Sponsor
- University of Gaziantep
- Brief Summary
Migraine is a common and possible hereditary disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.The CHRNA7 gene has a major role in the neuropsychiatric phenotypes observed in patients. The 15q13.3 gain/loss variation in this gene may be associated with migraine.
- Detailed Description
Migraine is a common neurological disorder. Although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease. Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
Migraine
Vascular problems
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Case-Control Migraine CNV Copy number variation Case-Control 1 Migraine CNV Gene expression
- Primary Outcome Measures
Name Time Method CNV number 1 year CNV number effect on migraine
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medicine
🇹🇷Gaziantep, Şehitkamil, Turkey