Effects of Weight on Inflammation and Colon Cancer Risk
Completed
- Conditions
- Colorectal Cancer
- Interventions
- Other: no intervention
- Registration Number
- NCT02884024
- Lead Sponsor
- Tufts University
- Brief Summary
An observational study designed to compare colonic cytokine concentrations in lean versus obese individuals
- Detailed Description
An observational study was performed on 43 individuals undergoing routine screening colonoscopy, some of whom were lean and some who were obese. They had weight, height, and waist-hip ratio measured at the time of colonoscopy and had additional colonic biopsies to measure colonic cytokines.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 43
Inclusion Criteria
- Caucasian
- undergoing clinically-indicated screening colonoscopy
- BMI< or = 25, or 30+
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Exclusion Criteria
- past history of cancer (except non-melanoma skin cancer)
- a polyposis syndrome
- any current or chronic inflammatory disease or infection
- incapable of providing valid informed consent
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description mildly obese no intervention healthy subject undergoing routine screening colonoscopy, BMI 30-33.9 moderate-to-severe obese no intervention healthy subject undergoing routine screening colonoscopy, BMI 34+ lean no intervention healthy subject undergoing routine screening colonoscopy, BMI\< or = 25
- Primary Outcome Measures
Name Time Method colonic concentration of Interleukin-6 time zero: at baseline colonic concentration of Interleukin-1 beta time zero: at baseline colonic concentration of Interferon-gamma time zero: at baseline colonic concentration of Tumor Necrosis Factor-alpha time zero: at baseline
- Secondary Outcome Measures
Name Time Method